ID3 (gene)

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesID3, HEIR-1, bHLHb25, inhibitor of DNA binding 3, HLH protein
External IDsOMIM: 600277 MGI: 96398 HomoloGene: 1633 GeneCards: ID3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ID3
Genomic location for ID3
Band1p36.12Start23,557,926 bp[1]
End23,559,501 bp[1]
RNA expression pattern
PBB GE ID3 207826 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 23.56 – 23.56 MbChr 4: 136.14 – 136.15 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.[5][6]


Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.[supplied by OMIM][6]


ID3 (gene) has been shown to interact with TCF3.[7][8]

Repressors of ID3[edit]

BTG2 binds to the promoter of Id3 and represses its activity. By this mechanism, the upregulation of Id3 in the hippocampus caused by BTG2 ablation prevents terminal differentiation of hippocampal neurons.[9]

See also[edit]


  1. ^ a b c ENSG00000117318 GRCh38: Ensembl release 89: ENSG00000283060, ENSG00000117318 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007872 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A (Aug 1992). "Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development". EMBO J. 11 (7): 2563–71. doi:10.1002/j.1460-2075.1992.tb05321.x. PMC 556731. PMID 1628620.
  6. ^ a b "Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein".
  7. ^ Deed RW, Jasiok M, Norton JD (Apr 1998). "Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells". J. Biol. Chem. 273 (14): 8278–86. doi:10.1074/jbc.273.14.8278. PMID 9525934.
  8. ^ Langlands K, Yin X, Anand G, Prochownik EV (Aug 1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785–93. doi:10.1074/jbc.272.32.19785. PMID 9242638.
  9. ^ Farioli-Vecchioli S, Saraulli D, Costanzi M, Leonardi L, Cinà I, Micheli L, Nutini M, Longone P, Oh SP, Cestari V, Tirone F (2009). Okazawa H (ed.). "Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice". PLoS ONE. 4 (12): e8339. doi:10.1371/journal.pone.0008339. PMC 2791842. PMID 20020054.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.