ID3 (gene)

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Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ID3 ; HEIR-1; bHLHb25
External IDs OMIM600277 MGI96398 HomoloGene1633 GeneCards: ID3 Gene
RNA expression pattern
PBB GE ID3 207826 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3399 15903
Ensembl ENSG00000117318 ENSMUSG00000007872
UniProt Q02535 P41133
RefSeq (mRNA) NM_002167 NM_008321
RefSeq (protein) NP_002158 NP_032347
Location (UCSC) Chr 1:
23.56 – 23.56 Mb
Chr 4:
136.14 – 136.15 Mb
PubMed search [1] [2]

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.[1][2]


Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.[supplied by OMIM][2]


ID3 (gene) has been shown to interact with TCF3.[3][4]

Repressors of ID3[edit]

BTG2 binds to the promoter of Id3 and represses its activity. By this mechanism, the upregulation of Id3 in the hippocampus caused by BTG2 ablation prevents terminal differentiation of hippocampal neurons.[5]

See also[edit]


  1. ^ Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A (Aug 1992). "Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development". EMBO J. 11 (7): 2563–71. PMC 556731. PMID 1628620. 
  2. ^ a b "Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein". 
  3. ^ Deed RW, Jasiok M, Norton JD (Apr 1998). "Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells". J. Biol. Chem. 273 (14): 8278–86. doi:10.1074/jbc.273.14.8278. PMID 9525934. 
  4. ^ Langlands K, Yin X, Anand G, Prochownik EV (Aug 1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785–93. doi:10.1074/jbc.272.32.19785. PMID 9242638. 
  5. ^ Farioli-Vecchioli S, Saraulli D, Costanzi M, Leonardi L, Cinà I, Micheli L, Nutini M, Longone P, Oh SP, Cestari V, Tirone F (2009). Okazawa H, ed. "Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice". PLoS ONE 4 (12): e8339. doi:10.1371/journal.pone.0008339. PMC 2791842. PMID 20020054. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.