From Wikipedia, the free encyclopedia
Jump to: navigation, search
Heat shock transcription factor 2
Symbols HSF2 ; HSF 2; HSTF 2
External IDs OMIM140581 MGI96239 HomoloGene37931 GeneCards: HSF2 Gene
RNA expression pattern
PBB GE HSF2 209657 s at tn.png
PBB GE HSF2 211220 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3298 15500
Ensembl ENSG00000025156 ENSMUSG00000019878
UniProt Q03933 P38533
RefSeq (mRNA) NM_001135564 NM_008297
RefSeq (protein) NP_001129036 NP_032323
Location (UCSC) Chr 6:
122.4 – 122.43 Mb
Chr 10:
57.49 – 57.51 Mb
PubMed search [1] [2]

Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.[1][2]


HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.[2]


HSF2 has been shown to interact with Nucleoporin 62[3] and HSF1.[4]

See also[edit]


  1. ^ Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (Sep 1991). "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans". Proc Natl Acad Sci U S A 88 (16): 6911–5. doi:10.1073/pnas.88.16.6911. PMC 52203. PMID 1871106. 
  2. ^ a b "Entrez Gene: HSF2 heat shock transcription factor 2". 
  3. ^ Yoshima T, Yura T, Yanagi H (Nov 1997). "The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62". Biochem. Biophys. Res. Commun. 240 (1): 228–33. doi:10.1006/bbrc.1997.7662. PMID 9367915. 
  4. ^ He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK (Sep 2003). "Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress". J. Biol. Chem. 278 (37): 35465–75. doi:10.1074/jbc.M304663200. PMID 12813038. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.