HSF2

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HSF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHSF2, HSF 2, HSTF 2, heat shock transcription factor 2
External IDsMGI: 96239 HomoloGene: 37931 GeneCards: HSF2
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HSF2
Genomic location for HSF2
Band6q22.31Start122,399,546 bp[1]
End122,433,119 bp[1]
RNA expression pattern
PBB GE HSF2 209657 s at fs.png

PBB GE HSF2 211220 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004506
NM_001135564
NM_001243094

NM_008297

RefSeq (protein)

NP_001129036
NP_001230023
NP_004497
NP_001230023.1

NP_032323

Location (UCSC)Chr 6: 122.4 – 122.43 MbChr 10: 57.49 – 57.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.[5][6]

Function[edit]

HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.[6]

Interactions[edit]

HSF2 has been shown to interact with Nucleoporin 62[7] and HSF1.[8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000025156 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019878 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (Sep 1991). "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans". Proc Natl Acad Sci U S A. 88 (16): 6911–5. doi:10.1073/pnas.88.16.6911. PMC 52203. PMID 1871106.
  6. ^ a b "Entrez Gene: HSF2 heat shock transcription factor 2".
  7. ^ Yoshima T, Yura T, Yanagi H (Nov 1997). "The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62". Biochem. Biophys. Res. Commun. 240 (1): 228–33. doi:10.1006/bbrc.1997.7662. PMID 9367915.
  8. ^ He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK (Sep 2003). "Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress". J. Biol. Chem. 278 (37): 35465–75. doi:10.1074/jbc.M304663200. PMID 12813038.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.