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Folliculogenesis specific bHLH transcription factor
External IDs OMIM608697 MGI1349421 HomoloGene49294 GeneCards: FIGLA Gene
Species Human Mouse
Entrez 344018 26910
Ensembl ENSG00000183733 ENSMUSG00000030001
UniProt Q6QHK4 O55208
RefSeq (mRNA) NM_001004311 NM_012013
RefSeq (protein) NP_001004311 NP_036143
Location (UCSC) Chr 2:
70.78 – 70.79 Mb
Chr 6:
86.02 – 86.02 Mb
PubMed search [1] [2]

Folliculogenesis-specific basic helix-loop-helix, also known as factor in the germline alpha (FIGalpha) or transcription factor FIGa, is a protein that in humans is encoded by the FIGLA gene.[1][2]


This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida.[1]

Clinical significance[edit]

Mutation in the FIGLA gene are associated with premature ovarian failure.[3]


  1. ^ a b "Entrez Gene: folliculogenesis specific basic helix-loop-helix". 
  2. ^ Huntriss J, Gosden R, Hinkins M, Oliver B, Miller D, Rutherford AJ, Picton HM (December 2002). "Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes". Mol. Hum. Reprod. 8 (12): 1087–95. doi:10.1093/molehr/8.12.1087. PMID 12468641. 
  3. ^ Zhao H, Chen ZJ, Qin Y; et al. (June 2008). "Transcription factor FIGLA is mutated in patients with premature ovarian failure". Am. J. Hum. Genet. 82 (6): 1342–8. doi:10.1016/j.ajhg.2008.04.018. PMC 2427265. PMID 18499083. 

Further reading[edit]