GABPA

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GABPA
Protein GABPA PDB 1awc.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07, GA binding protein transcription factor alpha subunit, GA binding protein transcription factor subunit alpha
External IDsOMIM: 600609 MGI: 95610 HomoloGene: 1543 GeneCards: GABPA
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for GABPA
Genomic location for GABPA
Band21q21.3Start25,734,570 bp[1]
End25,772,460 bp[1]
RNA expression pattern
PBB GE GABPA 210188 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001197297
NM_002040

NM_008065

RefSeq (protein)

NP_001184226
NP_002031
NP_002031.2

NP_032091

Location (UCSC)Chr 21: 25.73 – 25.77 MbChr 16: 84.83 – 84.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.[5]

Function[edit]

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.[6]

Interactions[edit]

GABPA has been shown to interact with Host cell factor C1,[7] Sp1 transcription factor[8] and Sp3 transcription factor.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154727 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008976 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Watanabe H, Sawada J, Yano K, Yamaguchi K, Goto M, Handa H (Mar 1993). "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs". Molecular and Cellular Biology. 13 (3): 1385–91. doi:10.1128/MCB.13.3.1385. PMC 359448. PMID 8441384.
  6. ^ "Entrez Gene: GABPA GA binding protein transcription factor, alpha subunit 60kDa".
  7. ^ Vogel JL, Kristie TM (Feb 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". The EMBO Journal. 19 (4): 683–90. doi:10.1093/emboj/19.4.683. PMC 305606. PMID 10675337.
  8. ^ a b Galvagni F, Capo S, Oliviero S (Mar 2001). "Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter" (PDF). Journal of Molecular Biology. 306 (5): 985–96. doi:10.1006/jmbi.2000.4335. hdl:2318/141203. PMID 11237613.

Further reading[edit]

External links[edit]