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GA binding protein transcription factor, alpha subunit 60kDa
Protein GABPA PDB 1awc.png
PDB rendering based on 1awc.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GABPA ; E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A; RCH04A07
External IDs OMIM600609 MGI95610 HomoloGene1543 GeneCards: GABPA Gene
RNA expression pattern
PBB GE GABPA 210188 at tn.png
More reference expression data
Species Human Mouse
Entrez 2551 14390
Ensembl ENSG00000154727 ENSMUSG00000008976
UniProt Q06546 Q00422
RefSeq (mRNA) NM_001197297 NM_008065
RefSeq (protein) NP_001184226 NP_032091
Location (UCSC) Chr 21:
25.73 – 25.77 Mb
Chr 16:
84.83 – 84.86 Mb
PubMed search [1] [2]

GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.[1]


This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.[2]


GABPA has been shown to interact with Host cell factor C1,[3] Sp1 transcription factor[4] and Sp3 transcription factor.[4]


  1. ^ Watanabe H, Sawada J, Yano K, Yamaguchi K, Goto M, Handa H (Mar 1993). "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs". Molecular and Cellular Biology 13 (3): 1385–91. PMC 359448. PMID 8441384. 
  2. ^ "Entrez Gene: GABPA GA binding protein transcription factor, alpha subunit 60kDa". 
  3. ^ Vogel JL, Kristie TM (Feb 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". The EMBO Journal 19 (4): 683–90. doi:10.1093/emboj/19.4.683. PMC 305606. PMID 10675337. 
  4. ^ a b Galvagni F, Capo S, Oliviero S (Mar 2001). "Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter". Journal of Molecular Biology 306 (5): 985–96. doi:10.1006/jmbi.2000.4335. PMID 11237613. 

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