HMGA

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high mobility group AT-hook 1
Identifiers
SymbolHMGA1
Alt. symbolsHMGIY
Entrez3159
HUGO5010
OMIM600701
RefSeqNM_145901
UniProtP17096
Other data
LocusChr. 6 p21
high mobility group AT-hook 2
Identifiers
SymbolHMGA2
Alt. symbolsHMGIC
Entrez8091
HUGO5009
OMIM600698
RefSeqNM_003484
UniProtP52926
Other data
LocusChr. 12 q15

HMGA is a family of high mobility group proteins characterized by an AT-hook. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture".[1] A 2007 study showed variations in HMGA2 to have a moderate association with adult height.[2][3]

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References[edit]

  1. ^ Mayr C, Hemann MT, Bartel DP (2007). "Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation". Science. 315 (5818): 1576–1579. doi:10.1126/science.1137999. PMC 2556962. PMID 17322030.
  2. ^ "Scientists discover height gene". BBC News. 2007-09-03. Retrieved 2007-09-03.
  3. ^ Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM (2007). "A common variant of HMGA2 is associated with adult and childhood height in the general population". Nat. Genet. 39 (10): 1245–1250. doi:10.1038/ng2121. PMC 3086278. PMID 17767157.

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