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high mobility group AT-hook 1
Symbol HMGA1
Alt. symbols HMGIY
Entrez 3159
HUGO 5010
OMIM 600701
RefSeq NM_145901
UniProt P17096
Other data
Locus Chr. 6 p21
high mobility group AT-hook 2
Symbol HMGA2
Alt. symbols HMGIC
Entrez 8091
HUGO 5009
OMIM 600698
RefSeq NM_003484
UniProt P52926
Other data
Locus Chr. 12 q15

HMGA is a family of high mobility group proteins characterized by an AT-hook. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture".[1] A 2007 study showed variations in HMGA2 to have a moderate association with adult height.[2][3]

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  1. ^ Mayr C, Hemann MT, Bartel DP (2007). "Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation". Science 315 (5818): 1576–1579. doi:10.1126/science.1137999. PMC 2556962. PMID 17322030. 
  2. ^ "Scientists discover height gene". BBC News. 2007-09-03. Retrieved 2007-09-03. 
  3. ^ Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM (2007). "A common variant of HMGA2 is associated with adult and childhood height in the general population". Nat. Genet. 39 (10): 1245–1250. doi:10.1038/ng2121. PMC 3086278. PMID 17767157. 

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