MLX (gene)

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MLX, MAX dimerization protein
Symbols MLX ; MAD7; MXD7; TCFL4; bHLHd13
External IDs OMIM602976 MGI108398 HomoloGene7969 GeneCards: MLX Gene
RNA expression pattern
PBB GE MLX 213708 s at tn.png
PBB GE MLX 210752 s at tn.png
PBB GE MLX 217909 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6945 21428
Ensembl ENSG00000108788 ENSMUSG00000017801
UniProt Q9UH92 O08609
RefSeq (mRNA) NM_170607 NM_001159384
RefSeq (protein) NP_733752 NP_001152856
Location (UCSC) Chr 17:
42.57 – 42.57 Mb
Chr 11:
101.09 – 101.09 Mb
PubMed search [1] [2]

Max-like protein X is a protein that in humans is encoded by the MLX gene.[1][2]

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[2]


MLX (gene) has been shown to interact with MNT,[3][4] MXD1[3][4] and MLXIPL.[3]


  1. ^ Bjerknes M, Cheng H (January 1997). "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene 181 (1–2): 7–11. doi:10.1016/S0378-1119(96)00376-9. PMID 8973301. 
  2. ^ a b "Entrez Gene: MLX MAX-like protein X". 
  3. ^ a b c Cairo, S; Merla G; Urbinati F; Ballabio A; Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. (England) 10 (6): 617–27. doi:10.1093/hmg/10.6.617. ISSN 0964-6906. PMID 11230181. 
  4. ^ a b Meroni, G; Cairo S; Merla G; Messali S; Brent R; Ballabio A; Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene (ENGLAND) 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. ISSN 0950-9232. PMID 10918583. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.