MLX (gene)

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MLX
Identifiers
AliasesMLX, MAD7, MXD7, TCFL4, bHLHd13, MAX dimerization protein, TF4, MAX dimerization protein MLX
External IDsMGI: 108398 HomoloGene: 7969 GeneCards: MLX
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for MLX
Genomic location for MLX
Band17q21.2Start42,567,068 bp[1]
End42,573,239 bp[1]
RNA expression pattern
PBB GE MLX 213708 s at fs.png

PBB GE MLX 217909 s at fs.png

PBB GE MLX 210752 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198205
NM_170607
NM_198204

NM_001159384
NM_001159385
NM_011550

RefSeq (protein)

NP_733752
NP_937847
NP_937848

NP_001152856
NP_001152857
NP_035680

Location (UCSC)Chr 17: 42.57 – 42.57 MbChr 11: 101.09 – 101.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Max-like protein X is a protein that in humans is encoded by the MLX gene.[5][6]

Function[edit]

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[6]

Interactions[edit]

MLX (gene) has been shown to interact with MNT,[7][8] MXD1[7][8] and MLXIPL.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108788 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017801 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Bjerknes M, Cheng H (November 1996). "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene. 181 (1–2): 7–11. doi:10.1016/S0378-1119(96)00376-9. PMID 8973301.
  6. ^ a b "Entrez Gene: MLX MAX-like protein X".
  7. ^ a b c Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181.
  8. ^ a b Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.