MLX (gene)

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MLX
Identifiers
Aliases MLX, MAD7, MXD7, TCFL4, bHLHd13, MAX dimerization protein
External IDs MGI: 108398 HomoloGene: 7969 GeneCards: 6945
RNA expression pattern
PBB GE MLX 210752 s at tn.png

PBB GE MLX 213708 s at tn.png

PBB GE MLX 217909 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198205
NM_170607
NM_198204

NM_001159384
NM_001159385
NM_011550

RefSeq (protein)

NP_733752.1
NP_937847.1
NP_937848.1

NP_001152856.1
NP_001152857.1
NP_035680.3

Location (UCSC) Chr 17: 42.57 – 42.57 Mb Chr 11: 101.09 – 101.09 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Max-like protein X is a protein that in humans is encoded by the MLX gene.[3][4]

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[4]

Interactions[edit]

MLX (gene) has been shown to interact with MNT,[5][6] MXD1[5][6] and MLXIPL.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bjerknes M, Cheng H (January 1997). "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene. 181 (1–2): 7–11. doi:10.1016/S0378-1119(96)00376-9. PMID 8973301. 
  4. ^ a b "Entrez Gene: MLX MAX-like protein X". 
  5. ^ a b c Cairo, S; Merla G; Urbinati F; Ballabio A; Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. England. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. ISSN 0964-6906. PMID 11230181. 
  6. ^ a b Meroni, G; Cairo S; Merla G; Messali S; Brent R; Ballabio A; Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. ENGLAND. 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. ISSN 0950-9232. PMID 10918583. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.