Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2gene.
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.
^Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Feb 1995). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID7835890.
Aguado B, Campbell RD (1995). "The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein". Genomics25 (3): 650–9. doi:10.1016/0888-7543(95)80007-9. PMID7759099.
Katsanis N, Fitzgibbon J, Fisher EM (1996). "Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci". Genomics35 (1): 101–8. doi:10.1006/geno.1996.0328. PMID8661110.
Okada Y, Nagai R, Sato T, et al. (2004). "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood101 (12): 4748–56. doi:10.1182/blood-2002-02-0380. PMID12609849.
Longobardi E, Blasi F (2003). "Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation". J. Biol. Chem.278 (40): 39235–41. doi:10.1074/jbc.M304704200. PMID12871956.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID14667819.