PBX2

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PBX2
HoxB1-Pbx1 heterodimer binding DNA 1b72.png
Identifiers
Aliases PBX2, G17, HOX12, PBX2MHC, PBX homeobox 2
External IDs MGI: 1341793 HomoloGene: 48115 GeneCards: PBX2
Genetically Related Diseases
asthma[1]
RNA expression pattern
PBB GE PBX2 202876 s at fs.png

PBB GE PBX2 202875 s at fs.png

PBB GE PBX2 211096 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002586

NM_017463

RefSeq (protein)

NP_002577

NP_059491.1
NP_059491

Location (UCSC) Chr 6: 32.18 – 32.19 Mb Chr 17: 34.59 – 34.6 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.[4][5]

Function[edit]

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[5]

Interactions[edit]

PBX2 has been shown to interact with HOXA9.[6]

References[edit]

  1. ^ "Diseases that are genetically associated with PBX2 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Sep 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890. 
  5. ^ a b "Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2". 
  6. ^ Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. PMC 84099Freely accessible. PMID 10082572. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.