CEBPE

From Wikipedia, the free encyclopedia
Jump to: navigation, search
CEBPE
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CEBPE, C/EBP-epsilon, CRP1, CCAAT/enhancer binding protein epsilon
External IDs MGI: 103572 HomoloGene: 1367 GeneCards: CEBPE
Genetically Related Diseases
acute lymphocytic leukemia, lymphoblastic leukemia[1]
RNA expression pattern
PBB GE CEBPE 214523 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001805

NM_207131

RefSeq (protein)

NP_001796.2

NP_997014.1

Location (UCSC) Chr 14: 23.12 – 23.12 Mb Chr 14: 54.71 – 54.71 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene[4][5] and is pro-apoptotic.[6]

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.[4]

References[edit]

  1. ^ "Diseases that are genetically associated with CEBPE view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon". 
  5. ^ Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics. 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101. 
  6. ^ Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". The Journal of Biological Chemistry. 281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID 16531405. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.