CEBPE

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CEBPE
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CEBPE, C/EBP-epsilon, CRP1, CCAAT/enhancer binding protein epsilon
External IDs MGI: 103572 HomoloGene: 1367 GeneCards: 1053
Genetically Related Diseases
Disease Name References
acute lymphoblastic leukemia
lymphoblastic leukemia
RNA expression pattern
PBB GE CEBPE 214523 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001805

NM_207131

RefSeq (protein)

NP_001796.2

NP_997014.1

Location (UCSC) Chr 14: 23.12 – 23.12 Mb Chr 14: 54.71 – 54.71 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene[5][6] and is pro-apoptotic.[7]

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.[5]

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_9952&geneId=23353". 
  2. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_1037&geneId=23353". 
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon". 
  6. ^ Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics. 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101. 
  7. ^ Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". The Journal of Biological Chemistry. 281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID 16531405. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.