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Protein DLX2 PDB 2djn.png
Aliases DLX2, TES-1, TES1, AW121999, Dlx-2, distal-less homeobox 2
External IDs MGI: 94902 HomoloGene: 3244 GeneCards: DLX2
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DLX2
Genomic location for DLX2
Band 2q31.1 Start 172,099,439 bp[1]
End 172,102,900 bp[1]
RNA expression pattern
PBB GE DLX2 207147 at fs.png

PBB GE DLX2 215685 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 172.1 – 172.1 Mb Chr 2: 71.54 – 71.55 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene.[5][6]

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.[6]


DLX2 has been shown to interact with DLX5,[7] MSX1[7] and Msh homeobox 2.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115844 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023391 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ozcelik T, Porteus MH, Rubenstein JL, Francke U (Sep 1992). "DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2". Genomics. 13 (4): 1157–61. doi:10.1016/0888-7543(92)90031-M. PMID 1354641. 
  6. ^ a b "Entrez Gene: DLX2 distal-less homeobox 2". 
  7. ^ a b c Zhang, H; Hu G; Wang H; Sciavolino P; Iler N; Shen M M; Abate-Shen C (May 1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. UNITED STATES. 17 (5): 2920–32. doi:10.1128/mcb.17.5.2920. ISSN 0270-7306. PMC 232144Freely accessible. PMID 9111364. 

Further reading[edit]