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Distal-less homeobox 2
Protein DLX2 PDB 2djn.png
PDB rendering based on 2djn.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DLX2 ; TES-1; TES1
External IDs OMIM126255 MGI94902 HomoloGene3244 GeneCards: DLX2 Gene
RNA expression pattern
PBB GE DLX2 207147 at tn.png
PBB GE DLX2 215685 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1746 13392
Ensembl ENSG00000115844 ENSMUSG00000023391
UniProt Q07687 P40764
RefSeq (mRNA) NM_004405 NM_010054
RefSeq (protein) NP_004396 NP_034184
Location (UCSC) Chr 2:
172.1 – 172.1 Mb
Chr 2:
71.54 – 71.55 Mb
PubMed search [1] [2]

Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene.[1][2]

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.[2]


DLX2 has been shown to interact with DLX5,[3] MSX1[3] and Msh homeobox 2.[3]


  1. ^ Ozcelik T, Porteus MH, Rubenstein JL, Francke U (Sep 1992). "DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2". Genomics 13 (4): 1157–61. doi:10.1016/0888-7543(92)90031-M. PMID 1354641. 
  2. ^ a b "Entrez Gene: DLX2 distal-less homeobox 2". 
  3. ^ a b c Zhang, H; Hu G; Wang H; Sciavolino P; Iler N; Shen M M; Abate-Shen C (May 1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. (UNITED STATES) 17 (5): 2920–32. ISSN 0270-7306. PMC 232144. PMID 9111364. 

Further reading[edit]