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ELK3, ETS-domain protein (SRF accessory protein 2)
Symbols ELK3 ; ERP; NET; SAP-2; SAP2
External IDs OMIM600247 MGI101762 HomoloGene3833 ChEMBL: 1741184 GeneCards: ELK3 Gene
RNA expression pattern
PBB GE ELK3 206127 at tn.png
PBB GE ELK3 221773 at tn.png
More reference expression data
Species Human Mouse
Entrez 2004 13713
Ensembl ENSG00000111145 ENSMUSG00000008398
UniProt P41970 P41971
RefSeq (mRNA) NM_001303511 NM_001282967
RefSeq (protein) NP_001290440 NP_001269896
Location (UCSC) Chr 12:
96.19 – 96.27 Mb
Chr 10:
93.25 – 93.31 Mb
PubMed search [1] [2]

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.[1][2]

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.[2]


ELK3 has been shown to interact with TCF3.[3]


  1. ^ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904. 
  2. ^ a b "Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)". 
  3. ^ Maira, S M; Wurtz J M; Wasylyk B (Nov 1996). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. (ENGLAND) 15 (21): 5849–65. ISSN 0261-4189. PMC 452333. PMID 8918463. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.