ELK3

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
ELK3
Identifiers
AliasesELK3, ERP, NET, SAP2, SAP-2, ETS transcription factor, ETS transcription factor ELK3
External IDsMGI: 101762 HomoloGene: 3833 GeneCards: ELK3
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ELK3
Genomic location for ELK3
Band12q23.1Start96,194,375 bp[1]
End96,269,824 bp[1]
RNA expression pattern
PBB GE ELK3 206127 at fs.png

PBB GE ELK3 221773 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303511
NM_005230

NM_001282967
NM_013508
NM_205536
NM_001322265
NM_001322268

RefSeq (protein)

NP_001290440
NP_005221

NP_001269896
NP_001309194
NP_001309197
NP_038536

Location (UCSC)Chr 12: 96.19 – 96.27 MbChr 10: 93.25 – 93.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.[5][6]

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.[6]

Interactions[edit]

ELK3 has been shown to interact with TCF3.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111145 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008398 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics. 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.
  6. ^ a b "Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)".
  7. ^ Maira, S M; Wurtz J M; Wasylyk B (Nov 1996). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. ENGLAND. 15 (21): 5849–65. ISSN 0261-4189. PMC 452333. PMID 8918463.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.