ELK3

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ELK3
Identifiers
Aliases ELK3, ERP, NET, SAP2, SAP-2, ETS transcription factor
External IDs MGI: 101762 HomoloGene: 3833 GeneCards: 2004
RNA expression pattern
PBB GE ELK3 206127 at tn.png

PBB GE ELK3 221773 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303511
NM_005230

NM_001282967
NM_013508
NM_205536
NM_001322265
NM_001322268

RefSeq (protein)

NP_005221.2

NP_038536.2
NP_001309194.1
NP_001309197.1

Location (UCSC) Chr 12: 96.19 – 96.27 Mb Chr 10: 93.25 – 93.31 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.[3][4]

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.[4]

Interactions[edit]

ELK3 has been shown to interact with TCF3.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics. 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904. 
  4. ^ a b "Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)". 
  5. ^ Maira, S M; Wurtz J M; Wasylyk B (Nov 1996). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. ENGLAND. 15 (21): 5849–65. ISSN 0261-4189. PMC 452333free to read. PMID 8918463. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.