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Caudal type homeobox 1
Symbols CDX1 ; MGC116915
External IDs OMIM600746 MGI88360 HomoloGene1366 GeneCards: CDX1 Gene
RNA expression pattern
PBB GE CDX1 206430 at tn.png
More reference expression data
Species Human Mouse
Entrez 1044 12590
Ensembl ENSG00000113722 ENSMUSG00000024619
UniProt P47902 P18111
RefSeq (mRNA) NM_001804 NM_009880
RefSeq (protein) NP_001795 NP_034010
Location (UCSC) Chr 5:
150.17 – 150.18 Mb
Chr 18:
61.02 – 61.04 Mb
PubMed search [1] [2]

Homeobox protein CDX-1 is a protein that in humans is encoded by the CDX1 gene.[1][2]


This gene is a member of the caudal-related homeobox transcription factor family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.[2]


  1. ^ Bonner CA, Loftus SK, Wasmuth JJ (Jul 1995). "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene". Genomics 28 (2): 206–11. doi:10.1006/geno.1995.1132. PMID 8530027. 
  2. ^ a b "Entrez Gene: CDX1 caudal type homeobox transcription factor 1". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.