CDX1

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CDX1
Identifiers
Aliases CDX1, caudal type homeobox 1, Homeobox protein CDX-1
External IDs MGI: 88360 HomoloGene: 1366 GeneCards: CDX1
RNA expression pattern
PBB GE CDX1 206430 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001804

NM_009880

RefSeq (protein)

NP_001795.2

NP_034010.3

Location (UCSC) Chr 5: 150.17 – 150.18 Mb Chr 18: 61.02 – 61.04 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein CDX-1 is a protein that in humans is encoded by the CDX1 gene.[3][4]

Function[edit]

This gene is a member of the caudal-related homeobox transcription factor family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bonner CA, Loftus SK, Wasmuth JJ (Jul 1995). "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene". Genomics. 28 (2): 206–11. doi:10.1006/geno.1995.1132. PMID 8530027. 
  4. ^ a b "Entrez Gene: CDX1 caudal type homeobox transcription factor 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.