CDX1

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CDX1
Identifiers
AliasesCDX1, caudal type homeobox 1, Homeobox protein CDX-1
External IDsMGI: 88360 HomoloGene: 1366 GeneCards: CDX1
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CDX1
Genomic location for CDX1
Band5q32Start150,166,795 bp[1]
End150,184,558 bp[1]
RNA expression pattern
PBB GE CDX1 206430 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001804

NM_009880

RefSeq (protein)

NP_001795

NP_034010

Location (UCSC)Chr 5: 150.17 – 150.18 MbChr 18: 61.02 – 61.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein CDX-1 is a protein in humans that is encoded by the CDX1 gene.[5][6] CDX1 is expressed in the developing endoderm and its expression persists in the intestine throughout adulthood.[7] CDX1 protein expression varies along the intestine, with high expression in intestinal crypts and diminishing expression along intestinal villi.[8]

Function[edit]

This gene is a member of the caudal-related homeobox transcription factor family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.[6]

CDX1 has also been shown to play an important role in embryonic epicardial development. It has been demonstrated that CDX proteins suppress cardiac differentiation in both zebrafish and mouse embryonic stem cells, but the overall mechanism for how this happens is poorly understood.[9] However, CDX1 has been shown to be transiently expressed in the embryonic heart 11.5 days post coitum (dpc). This transient expression is thought to induce epicardial epithelial-to-mesynchemal transition and thus proper cardiovascular formation. It has been shown that low-dose CDX1 induction caused enhanced migration and differentiation of epicardium-derived cells into vascular smooth muscle, where as continued high dose induction of CDX1 or CDX1 deficiency diminished the ability of these cells to migrate and differentiate into smooth muscle by the actions of TGF-β1. Furthermore, CDX1 induction also altered transcript expression of genes related to cell adhesions for EMT and angiogenesis.[10] Therefore, along with its known roles in intestinal patterning and differentiation, CDX1 is also shown to be important in epicardial development.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113722 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024619 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Bonner CA, Loftus SK, Wasmuth JJ (July 1995). "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene". Genomics. 28 (2): 206–11. doi:10.1006/geno.1995.1132. PMID 8530027. 
  6. ^ a b "Entrez Gene: CDX1 caudal type homeobox transcription factor 1". 
  7. ^ Grainger S, Hryniuk A, Lohnes D (2013). "Cdx1 and Cdx2 exhibit transcriptional specificity in the intestine". PLoS One. 8 (1): e54757. doi:10.1371/journal.pone.0054757. PMC 3559873Freely accessible. PMID 23382958. 
  8. ^ Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H (October 2007). "Identification of stem cells in small intestine and colon by marker gene Lgr5". Nature. 449 (7165): 1003–7. doi:10.1038/nature06196. PMID 17934449. 
  9. ^ Lengerke C, Wingert R, Beeretz M, Grauer M, Schmidt AG, Konantz M, Daley GQ, Davidson AJ (June 2011). "Interactions between Cdx genes and retinoic acid modulate early cardiogenesis". Developmental Biology. 354 (1): 134–42. doi:10.1016/j.ydbio.2011.03.027. PMC 3502019Freely accessible. PMID 21466798. 
  10. ^ Chu M, Wang L, Wang H, Shen T, Yang Y, Sun Y, Tang N, Ni T, Zhu J, Mailman RB, Wang Y (2014). "A novel role of CDX1 in embryonic epicardial development". PLoS One. 9 (7): e103271. doi:10.1371/journal.pone.0103271. PMC 4113346Freely accessible. PMID 25068460. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.