From Wikipedia, the free encyclopedia
Jump to: navigation, search
Human immunodeficiency virus type I enhancer binding protein 1
Protein HIVEP1 PDB 1bbo.png
PDB rendering based on 1bbo.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIVEP1 ; CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1; Schnurri-1; ZAS1; ZNF40; ZNF40A
External IDs OMIM194540 MGI96100 HomoloGene1596 ChEMBL: 2909 GeneCards: HIVEP1 Gene
RNA expression pattern
PBB GE HIVEP1 204512 at tn.png
More reference expression data
Species Human Mouse
Entrez 3096 110521
Ensembl ENSG00000095951 ENSMUSG00000021366
UniProt P15822 Q03172
RefSeq (mRNA) NM_002114 NM_007772
RefSeq (protein) NP_002105 NP_031798
Location (UCSC) Chr 6:
12.01 – 12.16 Mb
Chr 13:
42.05 – 42.19 Mb
PubMed search [1] [2]

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.[1][2]

Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][2]


  1. ^ Gaynor RB, Muchardt C, Diep A, Mohandas TK, Sparkes RS, Lusis AJ (Jul 1991). "Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24". Genomics 9 (4): 758–61. doi:10.1016/0888-7543(91)90371-K. PMID 2037300. 
  2. ^ a b "Entrez Gene: HIVEP1 human immunodeficiency virus type I enhancer binding protein 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.