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Basic helix-loop-helix family, member e40
Symbols BHLHE40 ; BHLHB2; DEC1; HLHB2; SHARP-2; STRA13; Stra14
External IDs OMIM604256 MGI1097714 HomoloGene2722 GeneCards: BHLHE40 Gene
RNA expression pattern
PBB GE BHLHB2 201170 s at tn.png
PBB GE BHLHB2 201169 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8553 20893
Ensembl ENSG00000134107 ENSMUSG00000030103
UniProt O14503 O35185
RefSeq (mRNA) NM_003670 NM_011498
RefSeq (protein) NP_003661 NP_035628
Location (UCSC) Chr 3:
4.98 – 4.99 Mb
Chr 6:
108.66 – 108.67 Mb
PubMed search [1] [2]

Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.[1][2][3][4]

DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.[4]


  1. ^ Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, Noshiro M, Kato Y (Aug 1997). "Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes". Biochem Biophys Res Commun 236 (2): 294–8. doi:10.1006/bbrc.1997.6960. PMID 9240428. 
  2. ^ Antonevich T, Taneja R (Oct 1999). "Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization". Cytogenet Cell Genet 85 (3-4): 254–5. doi:10.1159/000015305. PMID 10449910. 
  3. ^ Stevens JD, Roalson EH, Skinner MK (Dec 2008). "Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation". Differentiation 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMID 18557763. 
  4. ^ a b "Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.