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AliasesKLF6, BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9, Kruppel-like factor 6, Kruppel like factor 6
External IDsOMIM: 602053 MGI: 1346318 HomoloGene: 996 GeneCards: KLF6
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 10: 3.78 – 3.79 MbChr 13: 5.91 – 5.92 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.[5]

It is a tumor suppressor gene.[6]


This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.[7]


KLF6 has been shown to interact with Sp1 transcription factor.[8]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000067082 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000078 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Onyango P, Koritschoner NP, Patrito LC, Zenke M, Weith A (Feb 1998). "Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization". Genomics. 48 (1): 143–4. doi:10.1006/geno.1997.5124. PMID 9503030.
  6. ^ Li D, Yea S, Dolios G, Martignetti JA, Narla G, Wang R, Walsh MJ, Friedman SL (Oct 2005). "Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation". Cancer Research. 65 (20): 9216–25. doi:10.1158/0008-5472.CAN-05-1040. PMID 16230382.
  7. ^ "Entrez Gene: KLF6 Kruppel-like factor 6".
  8. ^ Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F, Kojima S, Shimada J, Guerrero-Esteo M, Cooreman MP, Ratziu V, Langa C, Vary CP, Ramirez JR, Friedman S, Bernabéu C (Dec 2002). "Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury". Blood. 100 (12): 4001–10. doi:10.1182/blood.V100.12.4001. PMID 12433697.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.