HIVEP2

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HIVEP2
Identifiers
Aliases HIVEP2, HIV-EP2, MBP-2, MIBP1, SHN2, ZAS2, ZNF40B, human immunodeficiency virus type I enhancer binding protein 2
External IDs MGI: 1338076 HomoloGene: 4900 GeneCards: 3097
RNA expression pattern
PBB GE HIVEP2 212641 at tn.png

PBB GE HIVEP2 212642 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006734

NM_010437

RefSeq (protein)

NP_006725.3

NP_034567.2

Location (UCSC) Chr 6: 142.75 – 142.95 Mb Chr 10: 13.97 – 14.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor HIVEP2 is a protein that in humans is encoded by the HIVEP2 gene.[1][2][3]

Function[edit]

Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][3]

References[edit]

  1. ^ Sudo T, Ozawa K, Soeda EI, Nomura N, Ishii S (January 1992). "Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24". Genomics 12 (1): 167–70. doi:10.1016/0888-7543(92)90423-P. PMID 1733857. 
  2. ^ Nomura N, Zhao MJ, Nagase T, Maekawa T, Ishizaki R, Tabata S, Ishii S (May 1991). "HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1". The Journal of Biological Chemistry 266 (13): 8590–4. PMID 2022670. 
  3. ^ a b "Entrez Gene: HIVEP2 human immunodeficiency virus type I enhancer binding protein 2". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.