The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.
^LeClerc S, Palaniswami R, Xie BX, Govindan MV (Sep 1991). "Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression". The Journal of Biological Chemistry266 (26): 17333–40. PMID1894621.
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID12168954.
Warriar N, Pagé N, Govindan MV (Aug 1996). "Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element". The Journal of Biological Chemistry271 (31): 18662–71. doi:10.1074/jbc.271.31.18662. PMID8702520.
Tikoo A, Czekay S, Viars C, White S, Heath JK, Arden K, Maruta H (Oct 2000). "p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas". Gene257 (1): 23–31. doi:10.1016/S0378-1119(00)00387-5. PMID11054565.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID11214970.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (Jan 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology23 (1): 94–101. doi:10.1038/nbt1046. PMID15592455.
Barberis D, Casazza A, Sordella R, Corso S, Artigiani S, Settleman J, Comoglio PM, Tamagnone L (Oct 2005). "p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling". Journal of Cell Science118 (Pt 20): 4689–700. doi:10.1242/jcs.02590. PMID16188938.
Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D (Jan 2006). "Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability". The Journal of Biological Chemistry281 (4): 2296–305. doi:10.1074/jbc.M511248200. PMID16308318.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID16341674.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983.
Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP (Aug 2007). "Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo". The Journal of Biological Chemistry282 (33): 23910–8. doi:10.1074/jbc.M702169200. PMID17562701.