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Rho GTPase activating protein 35
Protein ARHGAP35 PDB 2K85.png
Rendering based on PDB 2K85.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARHGAP35 ; GRF-1; GRLF1; P190-A; P190A; p190ARhoGAP; p190RhoGAP
External IDs OMIM605277 MGI1929494 HomoloGene35136 GeneCards: ARHGAP35 Gene
RNA expression pattern
PBB GE GRLF1 202046 s at tn.png
PBB GE GRLF1 202044 at tn.png
PBB GE GRLF1 gnf1h03426 at tn.png
More reference expression data
Species Human Mouse
Entrez 2909 232906
Ensembl ENSG00000160007 ENSMUSG00000058230
UniProt Q9NRY4 Q91YM2
RefSeq (mRNA) NM_004491 NM_172739
RefSeq (protein) NP_004482 NP_766327
Location (UCSC) Chr 19:
46.92 – 47.01 Mb
Chr 7:
16.49 – 16.61 Mb
PubMed search [1] [2]

Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.[1][2]

The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.[2]


  1. ^ LeClerc S, Palaniswami R, Xie BX, Govindan MV (Oct 1991). "Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression". J Biol Chem 266 (26): 17333–40. PMID 1894621. 
  2. ^ a b "Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1". 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.