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Jun B proto-oncogene
Symbols JUNB ; AP-1
External IDs OMIM165161 MGI96647 HomoloGene7390 GeneCards: JUNB Gene
RNA expression pattern
PBB GE JUNB 201473 at tn.png
More reference expression data
Species Human Mouse
Entrez 3726 16477
Ensembl ENSG00000171223 ENSMUSG00000052837
UniProt P17275 P09450
RefSeq (mRNA) NM_002229 NM_008416
RefSeq (protein) NP_002220 NP_032442
Location (UCSC) Chr 19:
12.79 – 12.79 Mb
Chr 8:
84.98 – 84.98 Mb
PubMed search [1] [2]

Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene.[1][2] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.


JUNB has been shown to interact with

See also[edit]


  1. ^ Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell 59 (6): 987–997. doi:10.1016/0092-8674(89)90755-1. PMID 2513129. 
  2. ^ "Entrez Gene: JUNB jun B proto-oncogene". 
  3. ^ Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. 16 (12): 1509–17. doi:10.1101/gad.995502. PMC 186344. PMID 12080089. 
  4. ^ Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (Apr 1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. doi:10.1073/pnas.96.9.4844. PMC 21779. PMID 10220381. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.