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Endogenous retrovirus group 3, member 1
Symbols ERV3-1 ; ERV-R; ERV3; ERVR; HERV-R; HERVR; envR
External IDs OMIM131170 HomoloGene128310 GeneCards: ERV3-1 Gene
RNA expression pattern
PBB GE ERV3 gnf1h04728 at tn.png
More reference expression data
Species Human Mouse
Entrez 2086 n/a
Ensembl ENSG00000213462 n/a
UniProt Q14264 n/a
RefSeq (mRNA) NM_001007253 n/a
RefSeq (protein) NP_001007254 n/a
Location (UCSC) Chr 7:
64.99 – 65.01 Mb
PubMed search [1] n/a

HERV-R_7q21.2 provirus ancestral Env polyprotein is a protein that in humans is encoded by the ERV3 gene.[1][2][3]

The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma.[3]


  1. ^ Kato N, Shimotohno K, VanLeeuwen D, Cohen M (Aug 1990). "Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Kruppel". Mol Cell Biol 10 (8): 4401–5. PMC 361000. PMID 2115127. 
  2. ^ O'Connell C, O'Brien S, Nash WG, Cohen M (Dec 1984). "ERV3, a full-length human endogenous provirus: chromosomal localization and evolutionary relationships". Virology 138 (2): 225–35. doi:10.1016/0042-6822(84)90347-7. PMID 6495650. 
  3. ^ a b "Entrez Gene: ERV3 endogenous retroviral sequence 3 (includes zinc finger protein H-plk/HPF9)". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.