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Nuclear factor, erythroid 2-like 3
Symbols NFE2L3 ; NRF3
External IDs OMIM604135 MGI1339958 HomoloGene3168 GeneCards: NFE2L3 Gene
Species Human Mouse
Entrez 9603 18025
Ensembl ENSG00000050344 ENSMUSG00000029832
UniProt Q9Y4A8 Q9WTM4
RefSeq (mRNA) NM_004289 NM_010903
RefSeq (protein) NP_004280 NP_035033
Location (UCSC) Chr 7:
26.15 – 26.19 Mb
Chr 6:
51.43 – 51.46 Mb
PubMed search [1] [2]

Nuclear factor erythroid 2-related factor 3, also known as NF-E2-related factor 3 or Nrf3, is a transcription factor that in humans is encoded by the NFE2L3 gene.[1][2]


This gene encodes a member of the cap 'n' collar basic-region leucine zipper (bZIP) family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors (MAF) to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope.[1]


  1. ^ a b "Entrez Gene: nuclear factor (erythroid-derived 2)-like 3". 
  2. ^ Kobayashi A, Ito E, Toki T, Kogame K, Takahashi S, Igarashi K, Hayashi N, Yamamoto M (March 1999). "Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3". J. Biol. Chem. 274 (10): 6443–52. doi:10.1074/jbc.274.10.6443. PMID 10037736. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.