HMGA

high mobility group AT-hook 2
high mobility group AT-hook 2
Identifiers
Symbol	HMGA2
Alt. symbols	HMGIC
NCBI gene	8091
HGNC	5009
OMIM	600698
RefSeq	NM_003484
UniProt	P52926
Other data
Locus	Chr. 12 q15
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

high mobility group AT-hook 1
high mobility group AT-hook 1
Identifiers
Symbol	HMGA1
Alt. symbols	HMGIY
NCBI gene	3159
HGNC	5010
OMIM	600701
RefSeq	NM_145901
UniProt	P17096
Other data
Locus	Chr. 6 p21
Structures
Search for
Structures	Swiss-model
Domains	InterPro

HMGA is a family of high mobility group proteins characterized by an AT-hook. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture".^[1] A 2007 study showed variations in HMGA2 to have a moderate association with adult height.^[2]^[3]

References

^ Mayr C, Hemann MT, Bartel DP (2007). "Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation". Science. 315 (5818): 1576–1579. doi:10.1126/science.1137999. PMC 2556962. PMID 17322030.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ "Scientists discover height gene". BBC News. 2007-09-03. Retrieved 2007-09-03.
^ Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM (2007). "A common variant of HMGA2 is associated with adult and childhood height in the general population". Nat. Genet. 39 (10): 1245–1250. doi:10.1038/ng2121. PMC 3086278. PMID 17767157.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links

HMGA+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[pmid17322030-1] Mayr C, Hemann MT, Bartel DP (2007). "Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation". Science. 315 (5818): 1576–1579. doi:10.1126/science.1137999. PMC 2556962. PMID 17322030.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[2] "Scientists discover height gene". BBC News. 2007-09-03. Retrieved 2007-09-03.

[pmid17767157-3] Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM (2007). "A common variant of HMGA2 is associated with adult and childhood height in the general population". Nat. Genet. 39 (10): 1245–1250. doi:10.1038/ng2121. PMC 3086278. PMID 17767157.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[1]

[2]

[3]

See also

References

External links