ZNF300

ZNF300
Identifiers
Aliases	ZNF300, zinc finger protein 300
External IDs	OMIM: 612429; HomoloGene: 56531; GeneCards: ZNF300; OMA:ZNF300 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,904,983 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; Achilles tendon; ; gonad; ; left ovary; ; right ovary; ; testicle; ; metanephros; ; left lobe of thyroid gland; ; body of pancreas;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	intracellular anatomical structure; nucleus; nucleolus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	91975
	n/a
	ENSG00000145908
	n/a
	Q96RE9
	n/a
	NM_001172831; NM_001172832; NM_052860
	n/a
	NP_001166302; NP_001166303; NP_443092
	n/a
	Wikidata
View/Edit Human

Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene.^[3]^[4] The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.

Clinical relevance

It is associated with Crohn's disease.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145908 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gou D, Wang J, Gao L, Sun Y, Peng X, Huang J, Li W (January 2004). "Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300". Biochim. Biophys. Acta. 1676 (2): 203–9. doi:10.1016/j.bbaexp.2003.11.011. PMID 14746915.
^ "Entrez Gene: zinc finger protein 300".
^ Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG (May 2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease". Hum. Mol. Genet. 19 (9): 1828–39. doi:10.1093/hmg/ddq041. PMC 2850616. PMID 20106866.

Feng T, Zhu X (2010). "Genome-wide searching of rare genetic variants in WTCCC data". Hum. Genet. 128 (3): 269–80. doi:10.1007/s00439-010-0849-9. PMC 2922446. PMID 20549515.
Qiu H, Xue L, Gao L, et al. (2008). "Identification of the DNA binding element of the human ZNF300 protein". Cell. Mol. Biol. Lett. 13 (3): 391–403. doi:10.2478/s11658-008-0005-x. PMID 18350257.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Xu JH, Wang T, Wang XG, et al. (2010). "PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60". Leuk. Res. 34 (12): 1636–46. doi:10.1016/j.leukres.2010.04.009. PMID 20471086.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Xue L, Qiu H, Ma J, et al. (2010). "ZNF300, a recently identified human transcription factor, activates the human IL-2RÎ² promoter through the overlapping ZNF300/EGR1 binding site". Cell. Mol. Biol. Lett. 15 (4): 530–40. doi:10.2478/s11658-010-0025-1. PMID 20585888.
Oh JH, Yang JO, Hahn Y, et al. (2005). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cao Y, Li JX, Ji CN, et al. (2007). "Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis". DNA Seq. 18 (4): 312–5. doi:10.1080/10425170701243393. PMID 17541838.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature. 447 (7145): 661–78. 2007. doi:10.1038/nature05911. PMC 2719288. PMID 17554300.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145908 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14746915-3] Gou D, Wang J, Gao L, Sun Y, Peng X, Huang J, Li W (January 2004). "Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300". Biochim. Biophys. Acta. 1676 (2): 203–9. doi:10.1016/j.bbaexp.2003.11.011. PMID 14746915.

[entrez-4] "Entrez Gene: zinc finger protein 300".

[pmid20106866-5] Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG (May 2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease". Hum. Mol. Genet. 19 (9): 1828–39. doi:10.1093/hmg/ddq041. PMC 2850616. PMID 20106866.

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Clinical relevance

References

Further reading