DLX gene family: Difference between revisions
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Known members of the family |
Known members of the family include Dlx1 to Dlx7. |
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Dlx genes are required for the tangential migration of [[interneuron]]s from the subpallium to the pallium during vertebrate [[brain development]] <ref>{{cite journal |
Dlx genes are required for the tangential migration of [[interneuron]]s from the subpallium to the pallium during vertebrate [[brain development]] <ref>{{cite journal |
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Revision as of 09:07, 14 January 2008
Dlx is a family of homeodomain transcription factors which are related to the Drosophila distal-less (Dll) gene [1].
The family has been related to a number of developmental features. The family seems to be well preserved across species[2].
Known members of the family include Dlx1 to Dlx7.
Dlx genes are required for the tangential migration of interneurons from the subpallium to the pallium during vertebrate brain development [3]. It has been suggested that Dlx promotes the migration of interneurons by repressing a set of proteins that are normally expressed in terminally differentiated neurons and act to promote the outgrowth of dendrites and axons [4]. Mice lacking Dlx1 exhibit electrophysiological and histological evidence consistent with delayed-onset epilepsy [5].
Dlx2 has been associated with a number of areas including development of the zona limitans intrathalamica and the prethalamus.
Dlx5/6 expression is necessary for normal lower jaw patterning in vertebrates [6].
Dlx7 is expressed in bone marrow[7].
References
- ^ Panganiban G (2002). "Developmental functions of the Distal-less/Dlx homeobox genes". Development. 129 (20): 4371–86. PMID 12223397.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ Stock DW (1996). "The evolution of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A. 93 (20): 10858–63. PMID 8855272.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ Anderson SA (1997). "Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes". Science. 278 (5337): 474–6. PMID 9334308.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ Cobos I (2007). "Dlx transcription factors promote migration through repression of axon and dendrite growth". Neuron. 54 (6): 873–88. PMID 17582329.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ Cobos I (2005). "Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy". Nat Neurosci. 8 (8): 1059–68. PMID 16007083.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ Depew MJ (2002). "Specification of jaw subdivisions by Dlx genes". Science. 298 (5592): 381-85. PMID 12193642.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ Takashi Shimamoto, (1997). "Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c-myc genes and apoptosis". Proc Natl Acad Sci U S A. 94 (7): 3245–9. PMID 9096378.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: extra punctuation (link)
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