Intracellular receptor: Difference between revisions
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'''Intracellular receptors''' are [[receptor (biochemistry)|receptor]]s located inside the [[cell (biology)|cell]] rather than on its [[cell membrane]]. Examples are the class of '''[[nuclear receptor]]s''' located in the [[cell nucleus]] and the [[IP3 receptor|IP<sub>3</sub> receptor]] located on the [[endoplasmic reticulum]]. The [[ligand]]s that bind to them are usually intracellular [[second messenger]]s like [[inositol trisphosphate]] (IP<sub>3</sub>) and extracellular [[lipophilicity|lipophilic]] [[hormone]]s like [[steroid hormone]]s. Some [[intracrine]] [[peptide hormone]]s also have intracellular receptors. |
'''Intracellular receptors''' (aka '''intramembrane receptors''') are [[receptor (biochemistry)|receptor]]s located inside the [[cell (biology)|cell]] rather than on its [[cell membrane]]. Examples are the class of '''[[nuclear receptor]]s''' located in the [[cell nucleus]] and the [[IP3 receptor|IP<sub>3</sub> receptor]] located on the [[endoplasmic reticulum]]. The [[ligand]]s that bind to them are usually intracellular [[second messenger]]s like [[inositol trisphosphate]] (IP<sub>3</sub>) and extracellular [[lipophilicity|lipophilic]] [[hormone]]s like [[steroid hormone]]s. Some [[intracrine]] [[peptide hormone]]s also have intracellular receptors. |
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== Members == |
== Members == |
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Revision as of 15:34, 10 June 2012
Intracellular receptors (aka intramembrane receptors) are receptors located inside the cell rather than on its cell membrane. Examples are the class of nuclear receptors located in the cell nucleus and the IP3 receptor located on the endoplasmic reticulum. The ligands that bind to them are usually intracellular second messengers like inositol trisphosphate (IP3) and extracellular lipophilic hormones like steroid hormones. Some intracrine peptide hormones also have intracellular receptors.
Members
- Steroid hormone receptor:
- Sex hormone receptors (sex hormones)
- Estrogen receptor (α and β)
- Androgen receptor (one type)
- Vitamin D receptor (vitamin D, one type)
- Glucocorticoid receptor (glucocorticoids, one type)
- Mineralocorticoid receptor (mineralocorticoids, one type)
- Sex hormone receptors (sex hormones)
- Thyroid hormone receptor (α and β)
- Retinoic acid receptor (vitamin A and related compounds);
- Peroxisome proliferator-activated receptors (PPARs, α, γ and δ)
- Retinoid X receptor
- Farnesoid X receptor
- Liver X receptor
- Pregnane X receptor
- Constitutive androstane receptor
Various
See also
External links
- Nuclear Receptor journal homepage
- Nuclear receptor resource at Georgetown University
- Nuclear receptor signalling atlas (NURSA, open-access journal)