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LMX1A

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LMX1A
Identifiers
AliasesLMX1A, LMX1, LMX1.1, LIM homeobox transcription factor 1 alpha, DFNA7
External IDsOMIM: 600298; MGI: 1888519; HomoloGene: 24921; GeneCards: LMX1A; OMA:LMX1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033507
NM_001174069
NM_177398
NM_177399

NM_033652

RefSeq (protein)

NP_001167540
NP_796372

NP_387501

Location (UCSC)Chr 1: 165.2 – 165.36 MbChr 1: 167.52 – 167.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.[5][6]

Function

Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene INS and interact with RNA polymerase to activate or repress transcription. LMX1 is a LIM homeobox transcription factor that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin.[7]

Interactions

LMX1A has been shown to interact with TCF3[8] and LHX3.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162761Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026686Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: LMX1A LIM homeobox transcription factor 1, alpha".
  6. ^ German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI (November 1994). "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13". Genomics. 24 (2): 403–4. doi:10.1006/geno.1994.1639. PMID 7698771.
  7. ^ "Entrez Gene: LMX1A".
  8. ^ Johnson JD, Zhang W, Rudnick A, Rutter WJ, German MS (Jul 1997). "Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity". Mol. Cell. Biol. 17 (7): 3488–96. doi:10.1128/mcb.17.7.3488. PMC 232202. PMID 9199284.
  9. ^ Jurata LW, Pfaff SL, Gill GN (Feb 1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152–7. doi:10.1074/jbc.273.6.3152. PMID 9452425.

Further reading