Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans is encoded by the FOXA3gene.[5][6]
Function
HNF-3G is a member of the forkheadclass of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.[5]
^Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID9119385.
Further reading
Corrocher R, Tedesco F, Rabusin P, De Sandre G (1975). "Effect of human erythrocyte stromata on complement activation". Br. J. Haematol. 29 (2): 235–41. doi:10.1111/j.1365-2141.1975.tb01817.x. PMID33.
Clark KL, Halay ED, Lai E, Burley SK (1993). "Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5". Nature. 364 (6436): 412–20. doi:10.1038/364412a0. PMID8332212.
Rodríguez-Antona C, Bort R, Jover R, et al. (2003). "Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma". Mol. Pharmacol. 63 (5): 1180–9. doi:10.1124/mol.63.5.1180. PMID12695546.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Navas MA, Vaisse C, Boger S, et al. (2000). "The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis". Hum. Hered. 50 (6): 370–81. doi:10.1159/000022943. PMID10899756.
Kaestner KH (2000). "The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism". Trends Endocrinol. Metab. 11 (7): 281–5. doi:10.1016/S1043-2760(00)00271-X. PMID10920385.
Lin B, Morris DW, Chou JY (1997). "The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation". Biochemistry. 36 (46): 14096–106. doi:10.1021/bi9703249. PMID9369482.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.