HOXC9

HOXC9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LP0, 2MSY
Identifiers
Aliases	HOXC9, HOX3, HOX3B, homeobox C9
External IDs	OMIM: 142971; MGI: 96199; HomoloGene: 130558; GeneCards: HOXC9; OMA:HOXC9 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.13 Start 53,994,895 bp End 54,003,337 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 F3|15 58.04 cM Start 102,884,874 bp End 102,893,531 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gastrocnemius muscle testicle gonad vastus lateralis muscle subcutaneous adipose tissue tibialis anterior muscle popliteal artery tibial arteries skin of leg Top expressed in tail of embryo female urethra ankle joint extensor digitorum longus muscle plantaris muscle muscle of thigh serosa of urinary bladder quadriceps femoris muscle soleus muscle epithelium of female urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm aggresome Biological process embryonic skeletal system morphogenesis multicellular organism development regulation of transcription, DNA-templated transcription, DNA-templated anterior/posterior pattern specification embryonic skeletal system development regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3225 15427 Ensembl ENSG00000180806 ENSMUSG00000036139 UniProt P31274 P09633 RefSeq (mRNA) NM_006897 NM_008272 RefSeq (protein) NP_008828 NP_032298 Location (UCSC) Chr 12: 53.99 – 54 Mb Chr 15: 102.88 – 102.89 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-C9 is a protein that in humans is encoded by the HOXC9 gene.

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12.

See also

• Homeobox

Further reading

• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (December 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (December 1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America. 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432.
• Redline RW, Hudock P, MacFee M, Patterson P (November 1994). "Expression of AbdB-type homeobox genes in human tumors". Laboratory Investigation; A Journal of Technical Methods and Pathology. 71 (5): 663–70. PMID 7967520.
• Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM (January 1996). "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proceedings of the National Academy of Sciences of the United States of America. 93 (2): 900–5. doi:10.1073/pnas.93.2.900. PMC 40155. PMID 8570656.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
• Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B (October 1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Letters. 415 (3): 263–7. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (February 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M (February 2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions". Nature. 427 (6976): 749–53. doi:10.1038/nature02305. hdl:11858/00-001M-0000-0012-EE32-1. PMID 14973489.
• Okamoto OK, Oba-Shinjo SM, Lopes L, Nagahashi Marie SK (2007). "Expression of HOXC9 and E2F2 are up-regulated in CD133(+) cells isolated from human astrocytomas and associate with transformation of human astrocytes". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1769 (7–8): 437–42. doi:10.1016/j.bbaexp.2007.05.002. PMID 17588684.

External links

• HOXC9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P31274 (Homeobox protein Hox-C9) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.