IKZF2

IKZF2
Identifiers
Aliases	IKZF2, ANF1A2, HELIOS, ZNF1A2, ZNFN1A2, IKAROS family zinc finger 2
External IDs	OMIM: 606234; MGI: 1342541; HomoloGene: 22659; GeneCards: IKZF2; OMA:IKZF2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q34 Start 212,999,691 bp End 213,152,427 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C3 Start 69,570,373 bp End 69,726,404 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus palpebral conjunctiva amniotic fluid mucosa of pharynx oral cavity gingival epithelium pancreatic epithelial cell mucosa of paranasal sinus epithelium of nasopharynx skin of thigh Top expressed in conjunctival fornix gastrula submandibular gland transitional epithelium of urinary bladder cornea lobe of prostate otolith organ utricle skin of external ear vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding protein homodimerization activity metal ion binding protein heterodimerization activity nucleic acid binding molecular function DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22807 22779 Ensembl ENSG00000030419 ENSMUSG00000025997 UniProt Q9UKS7 P81183 RefSeq (mRNA) NM_001079526 NM_016260 NM_001371274 NM_001371275 NM_001371276 NM_001371277 NM_001387220 NM_011770 RefSeq (protein) NP_001072994 NP_057344 NP_001358203 NP_001358204 NP_001358205 NP_001358206 NP_035900 NP_001389779 NP_001389781 NP_001389782 NP_001389783 NP_001389784 NP_001389785 NP_001389786 Location (UCSC) Chr 2: 213 – 213.15 Mb Chr 1: 69.57 – 69.73 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene.

Function

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Further reading

• Rebollo A, Schmitt C (Jun 2003). "Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies". Immunology and Cell Biology. 81 (3): 171–5. doi:10.1046/j.1440-1711.2003.01159.x. PMID 12752680. S2CID 43733744.
• Sridharan R, Smale ST (Oct 2007). "Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes". The Journal of Biological Chemistry. 282 (41): 30227–38. doi:10.1074/jbc.M702541200. PMID 17681952.
• Tabayashi T, Ishimaru F, Takata M, Kataoka I, Nakase K, Kozuka T, Tanimoto M (Feb 2007). "Characterization of the short isoform of Helios overexpressed in patients with T-cell malignancies". Cancer Science. 98 (2): 182–8. doi:10.1111/j.1349-7006.2006.00372.x. PMID 17297655. S2CID 9787574.
• Sun L, Kerawalla H, Wu X, Lehnert MS, Uckun FM (Apr 2002). "Expression of a unique helios isoform in human leukemia cells". Leukemia & Lymphoma. 43 (4): 841–9. doi:10.1080/10428190290016980. PMID 12153174. S2CID 8170745.
• Durand C, Kerfourn F, Charlemagne J, Fellah JS (Jun 2002). "Identification and expression of Helios, a member of the Ikaros family, in the Mexican axolotl: implications for the embryonic origin of lymphocyte progenitors". European Journal of Immunology. 32 (6): 1748–52. doi:10.1002/1521-4141(200206)32:6<1748::AID-IMMU1748>3.0.CO;2-B. PMID 12115658.
• Nakase K, Ishimaru F, Fujii K, Tabayashi T, Kozuka T, Sezaki N, Matsuo Y, Harada M (Apr 2002). "Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia". Experimental Hematology. 30 (4): 313–7. doi:10.1016/S0301-472X(01)00796-2. PMID 11937265.
• Perdomo J, Holmes M, Chong B, Crossley M (Dec 2000). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". The Journal of Biological Chemistry. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
• Hosokawa Y, Maeda Y, Seto M (Oct 1999). "Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern". Immunogenetics. 50 (1–2): 106–8. doi:10.1007/s002510050696. PMID 10541817. S2CID 39219337.

External links

• IKZF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.