ATF6

From Wikipedia, the free encyclopedia
  (Redirected from Activating transcription factor 6)
Jump to: navigation, search
ATF6
Identifiers
Aliases ATF6, ATF6A, ACHM7, activating transcription factor 6
External IDs MGI: 1926157 HomoloGene: 32015 GeneCards: ATF6
RNA expression pattern
PBB GE ATF6 203952 at fs.png

PBB GE ATF6 217550 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007348

NM_001081304

RefSeq (protein)

NP_031374

NP_001074773

Location (UCSC) Chr 1: 161.77 – 161.96 Mb Chr 1: 170.7 – 170.87 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[3][4][5] and is involved in the unfolded protein response.

Function[edit]

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[6] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

See also[edit]

Interactions[edit]

ATF6 has been shown to interact with YY1[7] and Serum response factor.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hai TW, Liu F, Coukos WJ, Green MR (December 1989). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. 3 (12B): 2083–90. PMID 2516827. doi:10.1101/gad.3.12b.2083. 
  4. ^ a b Zhu C, Johansen FE, Prywes R (September 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347Freely accessible. PMID 9271374. 
  5. ^ Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VM, Schalkwijk CG, Feskens EJ, Boer JM, Stehouwer CD, van der Kallen CJ, de Bruin TW (July 2007). "Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians". J. Clin. Endocrinol. Metab. 92 (7): 2720–5. PMID 17440018. doi:10.1210/jc.2006-2280. 
  6. ^ "Entrez Gene: ATF6 activating transcription factor 6". 
  7. ^ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Mol. Cell. Biol. 20 (14): 5096–106. PMC 85959Freely accessible. PMID 10866666. doi:10.1128/MCB.20.14.5096-5106.2000. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.