Homeobox protein CDX-1

CDX1
Identifiers
Aliases	CDX1, caudal type homeobox 1, Homeobox protein CDX-1
External IDs	OMIM: 600746; MGI: 88360; HomoloGene: 1366; GeneCards: CDX1; OMA:CDX1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,184,558 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	61,169,271 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; mucosa of ileum; ; mucosa of sigmoid colon; ; duodenum; ; gonad; ; jejunal mucosa; ; testicle; ; epithelium of colon; ; appendix;
	Top expressed in
	left colon; ; crypt of lieberkuhn of small intestine; ; ileum; ; primitive streak; ; Ileal epithelium; ; duodenum; ; Paneth cell; ; jejunum; ; embryo; ; migratory enteric neural crest cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; methyl-CpG binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	nucleus;
Biological process	animal organ morphogenesis; multicellular organism development; pattern specification process; bone morphogenesis; cell differentiation; anterior/posterior axis specification; regulation of transcription, DNA-templated; regulation of somitogenesis; positive regulation of transcription by RNA polymerase II; anterior/posterior pattern specification; transcription by RNA polymerase II; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1044
	12590
	ENSG00000113722
	ENSMUSG00000024619
	P47902
	P18111
	NM_001804
	NM_009880
	NP_001795
	NP_034010
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein CDX-1 is a protein that in humans is encoded by the CDX1 gene.^[5]^[6]

Function

This gene is a member of the caudal-related homeobox transcription factor family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113722 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024619 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bonner CA, Loftus SK, Wasmuth JJ (Jul 1995). "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene". Genomics. 28 (2): 206–11. doi:10.1006/geno.1995.1132. PMID 8530027.
^ ^a ^b "Entrez Gene: CDX1 caudal type homeobox transcription factor 1".

"Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group". Nature Genetics. 12 (2): 130–6. Feb 1996. doi:10.1038/ng0296-130. PMID 8563749.
Mallo GV, Rechreche H, Frigerio JM, Rocha D, Zweibaum A, Lacasa M, Jordan BR, Dusetti NJ, Dagorn JC, Iovanna JL (Feb 1997). "Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis". International Journal of Cancer. Journal International Du Cancer. 74 (1): 35–44. doi:10.1002/(SICI)1097-0215(19970220)74:1<35::AID-IJC7>3.0.CO;2-1. PMID 9036867.
Mizoshita T, Inada K, Tsukamoto T, Kodera Y, Yamamura Y, Hirai T, Kato T, Joh T, Itoh M, Tatematsu M (2002). "Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach". Gastric Cancer. 4 (4): 185–91. doi:10.1007/PL00011741. PMID 11846061.
Suh ER, Ha CS, Rankin EB, Toyota M, Traber PG (Sep 2002). "DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines". The Journal of Biological Chemistry. 277 (39): 35795–800. doi:10.1074/jbc.M205567200. PMID 12124393.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Domon-Dell C, Schneider A, Moucadel V, Guerin E, Guenot D, Aguillon S, Duluc I, Martin E, Iovanna J, Launay JF, Duclos B, Chenard MP, Meyer C, Oudet P, Kedinger M, Gaub MP, Freund JN (Sep 2003). "Cdx1 homeobox gene during human colon cancer progression". Oncogene. 22 (39): 7913–21. doi:10.1038/sj.onc.1206756. PMID 12970739.
Wong NA, Britton MP, Choi GS, Stanton TK, Bicknell DC, Wilding JL, Bodmer WF (Jan 2004). "Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines". Proceedings of the National Academy of Sciences of the United States of America. 101 (2): 574–9. doi:10.1073/pnas.0307190101. PMC 327189. PMID 14704280.
Rankin EB, Xu W, Silberg DG, Suh E (May 2004). "Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine". American Journal of Physiology. Gastrointestinal and Liver Physiology. 286 (5): G872-80. doi:10.1152/ajpgi.00326.2003. PMID 14715525.
Béland M, Pilon N, Houle M, Oh K, Sylvestre JR, Prinos P, Lohnes D (Jun 2004). "Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex". Molecular and Cellular Biology. 24 (11): 5028–38. doi:10.1128/MCB.24.11.5028-5038.2004. PMC 416402. PMID 15143193.
Guo RJ, Huang E, Ezaki T, Patel N, Sinclair K, Wu J, Klein P, Suh ER, Lynch JP (Aug 2004). "Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity". The Journal of Biological Chemistry. 279 (35): 36865–75. doi:10.1074/jbc.M405213200. PMID 15215241.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Alkhoury F, Malo MS, Mozumder M, Mostafa G, Hodin RA (Aug 2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2". American Journal of Physiology. Gastrointestinal and Liver Physiology. 289 (2): G285-90. doi:10.1152/ajpgi.00037.2005. PMID 15774940.
Wong NA, Wilding J, Bartlett S, Liu Y, Warren BF, Piris J, Maynard N, Marshall R, Bodmer WF (May 2005). "CDX1 is an important molecular mediator of Barrett's metaplasia". Proceedings of the National Academy of Sciences of the United States of America. 102 (21): 7565–70. doi:10.1073/pnas.0502031102. PMC 1140438. PMID 15894614.

External links

CDX1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113722 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024619 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530027-5] Bonner CA, Loftus SK, Wasmuth JJ (Jul 1995). "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene". Genomics. 28 (2): 206–11. doi:10.1006/geno.1995.1132. PMID 8530027.

[entrez-6] "Entrez Gene: CDX1 caudal type homeobox transcription factor 1".

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[3]

[4]

[5]

[6]

Function

References

Further reading

External links