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Interferon regulatory factor 9
Symbols IRF9 ; IRF-9; ISGF3; ISGF3G; p48
External IDs OMIM147574 MGI107587 HomoloGene4436 GeneCards: IRF9 Gene
Species Human Mouse
Entrez 10379 16391
Ensembl ENSG00000213928 ENSMUSG00000002325
UniProt Q00978 Q61179
RefSeq (mRNA) NM_006084 NM_001159417
RefSeq (protein) NP_006075 NP_001152889
Location (UCSC) Chr 14:
24.16 – 24.17 Mb
Chr 14:
55.6 – 55.61 Mb
PubMed search [1] [2]

Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G.[1][2][3]


IRF9 has been shown to interact with STAT2[4][5] and STAT1.[4]


  1. ^ Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, Darnell JE Jr, Levy DE (Aug 1992). "Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins". Mol Cell Biol 12 (8): 3315–24. PMC 364572. PMID 1630447. 
  2. ^ McCusker D, Wilson M, Trowsdale J (Jun 1999). "Organization of the genes encoding the human proteasome activators PA28alpha and beta". Immunogenetics 49 (5): 438–45. doi:10.1007/s002510050517. PMID 10199920. 
  3. ^ "Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa". 
  4. ^ a b Horvath, C M; Stark G R; Kerr I M; Darnell J E (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. (UNITED STATES) 16 (12): 6957–64. ISSN 0270-7306. PMC 231699. PMID 8943351. 
  5. ^ Martinez-Moczygemba, M; Gutch M J; French D L; Reich N C (Aug 1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. (UNITED STATES) 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. ISSN 0021-9258. PMID 9242679. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.