NFIC (gene)

NFIC
Identifiers
Aliases	NFIC, CTF, CTF5, NF-I, NFI, nuclear factor I C
External IDs	OMIM: 600729; MGI: 109591; HomoloGene: 4088; GeneCards: NFIC; OMA:NFIC - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,469,217 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,291,469 bp
RNA expression pattern
	Top expressed in
	nipple; ; parotid gland; ; cardia; ; pylorus; ; seminal vesicula; ; renal medulla; ; pericardium; ; urethra; ; trigeminal ganglion; ; body of tongue;
	Top expressed in
	ankle; ; lacrimal gland; ; triceps brachii muscle; ; aortic valve; ; extensor digitorum longus muscle; ; muscle of thigh; ; ascending aorta; ; plantaris muscle; ; vestibular membrane of cochlear duct; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; double-stranded DNA binding; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	intracellular anatomical structure; nucleus; fibrillar center;
Biological process	odontogenesis of dentin-containing tooth; DNA replication; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4782
	18029
	ENSG00000141905
	ENSMUSG00000055053
	P08651
	P70255
	NM_001245002; NM_001245004; NM_001245005; NM_005597; NM_205843
	NM_008688; NM_026756
	NP_001231931; NP_001231933; NP_001231934; NP_005588; NP_995315
	NP_032714; NP_081032
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141905 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055053 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Santoro C, Mermod N, Andrews PC, Tjian R (Aug 1988). "A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs". Nature. 334 (6179): 218–24. Bibcode:1988Natur.334..218S. doi:10.1038/334218a0. PMID 3398920. S2CID 4287831.
^ Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
^ "Entrez Gene: NFIC nuclear factor I/C (CCAAT-binding transcription factor)".

Blau J, Xiao H, McCracken S, et al. (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. doi:10.1128/MCB.16.5.2044. PMC 231191. PMID 8628270.
Wenzelides S, Altmann H, Wendler W, Winnacker EL (1996). "CTF5--a new transcriptional activator of the NFI/CTF family". Nucleic Acids Res. 24 (12): 2416–21. doi:10.1093/nar/24.12.2416. PMC 145930. PMID 8710515.
Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724.
Nogues G, Kadener S, Cramer P, et al. (2003). "Transcriptional activators differ in their abilities to control alternative splicing". J. Biol. Chem. 277 (45): 43110–4. doi:10.1074/jbc.M208418200. PMID 12221105.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Norquay LD, Yang X, Sheppard P, et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117.
Wickenheisser JK, Nelson-DeGrave VL, Quinn PG, McAllister JM (2004). "Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1". Mol. Endocrinol. 18 (3): 588–605. doi:10.1210/me.2003-0090. PMID 14684846.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhao LH, Ba XQ, Wang XG, et al. (2005). "BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation". Acta Biochim. Biophys. Sin. (Shanghai). 37 (7): 440–6. doi:10.1111/j.1745-7270.2005.00061.x. PMID 15999204.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Nilsson J, Bjursell G, Kannius-Janson M (2006). "Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells". Mol. Cell. Biol. 26 (15): 5663–74. doi:10.1128/MCB.02095-05. PMC 1592781. PMID 16847321.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Hebbar PB, Archer TK (2007). "Chromatin-dependent cooperativity between site-specific transcription factors in vivo". J. Biol. Chem. 282 (11): 8284–91. doi:10.1074/jbc.M610554200. PMC 2528297. PMID 17186943.

External links

NFIC+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141905 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055053 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3398920-5] Santoro C, Mermod N, Andrews PC, Tjian R (Aug 1988). "A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs". Nature. 334 (6179): 218–24. Bibcode:1988Natur.334..218S. doi:10.1038/334218a0. PMID 3398920. S2CID 4287831.

[pmid7590749-6] Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.

[entrez-7] "Entrez Gene: NFIC nuclear factor I/C (CCAAT-binding transcription factor)".

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References

Further reading

External links