NFIX

NFIX
Identifiers
Aliases	NFIX, MRSHSS, NF1A, SOTOS2, nuclear factor I X, NF1-X, NF-I/X, CTF, MALNS
External IDs	OMIM: 164005; MGI: 97311; HomoloGene: 1872; GeneCards: NFIX; OMA:NFIX - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.13 Start 12,995,475 bp End 13,098,796 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 C2|8 41.02 cM Start 84,699,876 bp End 84,800,344 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple ganglionic eminence inferior ganglion of vagus nerve postcentral gyrus internal globus pallidus ventral tegmental area tendon of biceps brachii buccal mucosa cell cardia urethra Top expressed in Rostral migratory stream internal carotid artery external carotid artery ankle utricle tunica media of zone of aorta subiculum ascending aorta lacrimal gland vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process DNA replication regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4784 18032 Ensembl ENSG00000008441 ENSMUSG00000001911 UniProt Q14938 P70257 RefSeq (mRNA) NM_001271043 NM_001271044 NM_002501 NM_001365902 NM_001365982 NM_001365983 NM_001365984 NM_001365985 NM_001378404 NM_001378405 NM_001081981 NM_001081982 NM_001297601 NM_010906 RefSeq (protein) NP_001257972 NP_001257973 NP_002492 NP_001352831 NP_001352911 NP_001352912 NP_001352913 NP_001352914 NP_001365333 NP_001365334 NP_001075450 NP_001075451 NP_001284530 NP_035036 NP_001357981 NP_001357982 NP_001357983 NP_001357984 NP_001357985 NP_001357986 NP_001357987 NP_001357988 NP_001357989 NP_001357990 NP_001357991 NP_001357992 Location (UCSC) Chr 19: 13 – 13.1 Mb Chr 8: 84.7 – 84.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.

Interactions

NFIX has been shown to interact with SKI protein and it is also known to interact with AP-1. NFI-X3 has been shown to interact with STAT3.

Further reading

• Apt D, Liu Y, Bernard HU (1994). "Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner". Nucleic Acids Res. 22 (19): 3825–33. doi:10.1093/nar/22.19.3825. PMC 308376. PMID 7937100.
• Sumner C, Shinohara T, Durham L, Traub R, Major EO, Amemiya K (1996). "Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes". J. Neurovirol. 2 (2): 87–100. doi:10.3109/13550289609146542. PMID 8799200.
• Wendler WM, Kremmer E, Förster R, Winnacker EL (1997). "Identification of pirin, a novel highly conserved nuclear protein". J. Biol. Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E (1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI". Nucleic Acids Res. 25 (19): 3895–903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514.
• Müller K, Mermod N (2000). "The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo". J. Biol. Chem. 275 (3): 1645–50. doi:10.1074/jbc.275.3.1645. PMID 10636857.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Nakazato M, Chung HK, Ulianich L, Grassadonia A, Suzuki K, Kohn LD (2000). "Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression". Mol. Cell. Biol. 20 (22): 8499–512. doi:10.1128/MCB.20.22.8499-8512.2000. PMC 102156. PMID 11046146.
• Imagawa M, Sakaue R, Tanabe A, Osada S, Nishihara T (2000). "Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A". FEBS Lett. 484 (2): 118–24. doi:10.1016/S0014-5793(00)02119-0. PMID 11068044.
• Norquay LD, Yang X, Sheppard P, Gregoire S, Dodd JG, Reith W, Cattini PA (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117.
• Gopalan SM, Wilczynska KM, Konik BS, Bryan L, Kordula T (2006). "Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes". J. Biol. Chem. 281 (19): 13126–33. doi:10.1074/jbc.M601194200. PMID 16565071.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Ravichandran V, Sabath BF, Jensen PN, Houff SA, Major EO (2006). "Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism". J. Virol. 80 (21): 10506–13. doi:10.1128/JVI.01355-06. PMC 1641797. PMID 16928756.

External links

• NFIX+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.