PEG3

PEG3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BHX
Identifiers
Aliases	PEG3, PW1, ZKSCAN22, ZNF904, ZSCAN24, paternally expressed 3
External IDs	OMIM: 601483; MGI: 104748; HomoloGene: 31363; GeneCards: PEG3; OMA:PEG3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	56,840,728 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	6,730,431 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; superior vestibular nucleus; ; lateral nuclear group of thalamus; ; Brodmann area 23; ; pons; ; Epithelium of choroid plexus; ; middle temporal gyrus; ; ventral tegmental area; ; external globus pallidus; ; dorsal motor nucleus of vagus nerve;
	Top expressed in
	umbilical cord; ; condyle; ; medullary collecting duct; ; pituitary gland; ; substantia nigra; ; ventromedial nucleus; ; fossa; ; human fetus; ; dorsomedial hypothalamic nucleus; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; autophagosome;
Biological process	apoptotic process; regulation of gene expression; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5178
	18616
	ENSG00000198300
	ENSMUSG00000002265
	Q9GZU2
	Q3URU2
	NM_006210; NM_001146184; NM_001146185; NM_001146186; NM_001146187
	NM_008817
	NP_001139656; NP_001139657; NP_001139658; NP_001139659; NP_006201
	NP_032843
	Wikidata
View/Edit Human	View/Edit Mouse

Paternally-expressed gene 3 protein is a protein that in humans is encoded by the Peg3 gene.^[5]^[6] Peg3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.^[7] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.^[8]

Template:PBB Summary

Interactions

PEG3 has been shown to interact with SIAH2^[9] and SIAH1.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198300 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002265 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res. 7 (5): 532–40. doi:10.1101/gr.7.5.532. PMC 310658. PMID 9149948.
^ "Entrez Gene: PEG3 paternally expressed 3".
^ Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". Retrieved May 22, 2014. {{cite web}}: Cite has empty unknown parameters: |1= and |2= (help)
^ Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–320. doi:10.1016/j.gene.2012.10.005. PMC 3513644. PMID 23078764.
^ ^a ^b Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. 97 (5). UNITED STATES: 2105–10. doi:10.1073/pnas.040378897. ISSN 0027-8424. PMC 15761. PMID 10681424. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading