PROP1

PROP1
Identifiers
Aliases	PROP1, CPHD2, PROP-1, PROP paired-like homeobox 1
External IDs	OMIM: 601538; MGI: 109330; HomoloGene: 4558; GeneCards: PROP1; OMA:PROP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,996,242 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	50,844,592 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary;
	Top expressed in
	anterior pituitary; ; Rathke's pouch; ; embryo; ; pars distalis of adenohypophysis; ; blastocyst; ; lumbar spinal ganglion; ; digastric muscle; ; lumbar subsegment of spinal cord; ; carotid body; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; beta-catenin binding; chromatin binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein C-terminus binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleus;
Biological process	regulation of transcription, DNA-templated; somatotropin secreting cell differentiation; hypothalamus cell differentiation; hypophysis morphogenesis; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; adenohypophysis development; central nervous system development; blood vessel development; animal organ morphogenesis; canonical Wnt signaling pathway; dorsal/ventral pattern formation; cell migration; positive regulation of transcription by RNA polymerase II; gland development;
	Sources:Amigo / QuickGO
Orthologs
	5626
	19127
	ENSG00000280635; ENSG00000175325; ENSG00000274382
	ENSMUSG00000044542
	O75360
	P97458
	NM_006261
	NM_008936
	NP_006252
	NP_032962
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein prophet of PIT-1 is a protein that in humans is encoded by the PROP1 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c ENSG00000175325, ENSG00000274382 GRCh38: Ensembl release 89: ENSG00000280635, ENSG00000175325, ENSG00000274382 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044542 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wu W, Cogan JD, Pfaffle RW, Dasen JS, Frisch H, O'Connell SM, Flynn SE, Brown MR, Mullis PE, Parks JS, Phillips JA III, Rosenfeld MG (Feb 1998). "Mutations in PROP1 cause familial combined pituitary hormone deficiency". Nat Genet. 18 (2): 147–9. doi:10.1038/ng0298-147. PMID 9462743.
^ "Entrez Gene: PROP1 prophet of Pit1, paired-like homeodomain transcription factor".

External links

GeneReviews/NCBI/NIH/UW entry on PROP1- Related Combined Pituitary Hormone Deficiency (CPHD)
PROP1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000175325, ENSG00000274382 GRCh38: Ensembl release 89: ENSG00000280635, ENSG00000175325, ENSG00000274382 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044542 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9462743-5] Wu W, Cogan JD, Pfaffle RW, Dasen JS, Frisch H, O'Connell SM, Flynn SE, Brown MR, Mullis PE, Parks JS, Phillips JA III, Rosenfeld MG (Feb 1998). "Mutations in PROP1 cause familial combined pituitary hormone deficiency". Nat Genet. 18 (2): 147–9. doi:10.1038/ng0298-147. PMID 9462743.

[entrez-6] "Entrez Gene: PROP1 prophet of Pit1, paired-like homeodomain transcription factor".

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References

Further reading

External links