PROX1

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PROX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPROX1, prospero homeobox 1
External IDsMGI: 97772 HomoloGene: 2069 GeneCards: PROX1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PROX1
Genomic location for PROX1
Band1q32.3Start213,983,181 bp[1]
End214,041,502 bp[1]
RNA expression pattern
PBB GE PROX1 207401 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270616
NM_002763

NM_008937
NM_001360827

RefSeq (protein)

NP_001257545
NP_002754

NP_032963
NP_001347756

Location (UCSC)Chr 1: 213.98 – 214.04 MbChr 1: 190.12 – 190.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene.[5][6]


Interactions[edit]

PROX1 has been shown to interact with EP300.[7]

Production[edit]

PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here.

Clinical significance[edit]

PROX1 is used as a marker for lymphatic endothelium in biopsy samples.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117707 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010175 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Zinovieva RD, Duncan MK, Johnson TR, Torres R, Polymeropoulos MH, Tomarev SI (Dec 1996). "Structure and chromosomal localization of the human homeobox gene Prox 1". Genomics. 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486.
  6. ^ "Entrez Gene: PROX1 prospero-related homeobox 1".
  7. ^ Chen, Qin; Dowhan Dennis H; Liang Dongcai; Moore David D; Overbeek Paul A (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. United States. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. ISSN 0021-9258. PMID 11943779.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.