USF1

USF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AN4
Identifiers
Aliases	USF1, FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11, upstream transcription factor 1
External IDs	OMIM: 191523; MGI: 99542; HomoloGene: 31426; GeneCards: USF1; OMA:USF1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,045,977 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,246,710 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; right lung; ; upper lobe of left lung; ; appendix; ; right hemisphere of cerebellum; ; spleen; ; bone marrow cells; ; mucosa of transverse colon; ; ganglionic eminence;
	Top expressed in
	ventricular zone; ; labioscrotal swelling; ; granulocyte; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; urethra; ; primary visual cortex; ; superior frontal gyrus; ; lip; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; histone deacetylase binding; bHLH transcription factor binding; protein binding; protein heterodimerization activity; enzyme binding; double-stranded DNA binding; protein kinase binding; protein homodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; sequence-specific DNA binding; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein-containing complex binding;
Cellular component	transcription regulator complex; nucleus; NURF complex; Set1C/COMPASS complex; nucleoplasm;
Biological process	carbon catabolite regulation of transcription; negative regulation of fibrinolysis; response to hypoxia; regulation of transcription, DNA-templated; glucose homeostasis; regulation of transcription by RNA polymerase II; late viral transcription; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; regulation of transcription from RNA polymerase II promoter by glucose; glucose metabolic process; cellular response to insulin stimulus; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter by glucose; lipid homeostasis; response to UV;
	Sources:Amigo / QuickGO
Orthologs
	7391
	22278
	ENSG00000158773
	ENSMUSG00000026641
	P22415
	Q61069
	NM_207005; NM_001276373; NM_007122
	NM_009480; NM_001305676; NM_001305677; NM_001305678
	NP_001263302; NP_009053; NP_996888
	NP_001292605; NP_001292606; NP_001292607; NP_033506
	Wikidata
View/Edit Human	View/Edit Mouse

Upstream stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene.^[5]^[6]

Function

This gene encodes a member of the basic helix-loop-helix leucine zipper family and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.^[6]

A study of mice suggested reduced USF1 levels increases metabolism in brown fat.^[7]

Interactions

USF1 (human gene) has been shown to interact with USF2,^[8]^[9] FOSL1^[10] and GTF2I.^[11]^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158773 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026641 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shieh BH, Sparkes RS, Gaynor RB, Lusis AJ (Apr 1993). "Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23". Genomics. 16 (1): 266–8. doi:10.1006/geno.1993.1174. PMID 8486371.
^ ^a ^b "Entrez Gene: USF1 upstream transcription factor 1".
^ Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, et al. (2016). "USF1 deficiency activates brown adipose tissue and improves cardiometabolic health". Science Translational Medicine. 8 (323): 323ra13. doi:10.1126/scitranslmed.aad0015. PMID 26819196.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.
^ Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG (Dec 1997). "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". The EMBO Journal. 16 (23): 7091–104. doi:10.1093/emboj/16.23.7091. PMC 1170311. PMID 9384587.
^ Roy AL, Meisterernst M, Pognonec P, Roeder RG (Nov 1991). "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature. 354 (6350): 245–8. doi:10.1038/354245a0. PMID 1961251.

External links

FactorBook USF1

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158773 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026641 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8486371-5] Shieh BH, Sparkes RS, Gaynor RB, Lusis AJ (Apr 1993). "Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23". Genomics. 16 (1): 266–8. doi:10.1006/geno.1993.1174. PMID 8486371.

[entrez-6] "Entrez Gene: USF1 upstream transcription factor 1".

[pmid26819196-7] Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, et al. (2016). "USF1 deficiency activates brown adipose tissue and improves cardiometabolic health". Science Translational Medicine. 8 (323): 323ra13. doi:10.1126/scitranslmed.aad0015. PMID 26819196.

[pmid17353931-8] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid8576131-9] Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid9160889-10] Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.

[pmid9384587-11] Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG (Dec 1997). "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". The EMBO Journal. 16 (23): 7091–104. doi:10.1093/emboj/16.23.7091. PMC 1170311. PMID 9384587.

[pmid1961251-12] Roy AL, Meisterernst M, Pognonec P, Roeder RG (Nov 1991). "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature. 354 (6350): 245–8. doi:10.1038/354245a0. PMID 1961251.

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[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

Function

Interactions

References

Further reading

External links