Y box binding protein 1

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Y box binding protein 1
Protein YBX1 PDB 1h95.png
PDB rendering based on 1h95.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols YBX1 ; BP-8; CSDA2; CSDB; DBPB; MDR-NF1; NSEP-1; NSEP1; YB-1; YB1
External IDs OMIM154030 HomoloGene88707 GeneCards: YBX1 Gene
Species Human Mouse
Entrez 4904 22608
Ensembl ENSG00000065978 ENSMUSG00000028639
UniProt P67809 P62960
RefSeq (mRNA) NM_004559 NM_011732
RefSeq (protein) NP_004550 NP_035862
Location (UCSC) Chr 1:
42.68 – 42.7 Mb
Chr 4:
119.28 – 119.29 Mb
PubMed search [1] [2]

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.[1]

Clinical significance[edit]

YBX1 is a potential drug target in cancer therapy.[2] YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy.[2] Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses


Y box binding protein 1 has been shown to interact with:


  1. ^ "Entrez Gene: YBX1 Y box binding protein 1". 
  2. ^ a b Lage H, Surowiak P, Holm PS (November 2008). "[YB-1 as a potential target in cancer therapy]". Pathologe (in German). 29 Suppl 2: 187–90. doi:10.1007/s00292-008-1030-2. PMID 18773210. 
  3. ^ a b Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G (2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. 339 (2): 313–25. doi:10.1016/j.jmb.2004.03.071. PMID 15136035. 
  4. ^ Chernukhin IV, Shamsuddin S, Robinson AF, Carne AF, Paul A, El-Kady AI, Lobanenkov VV, Klenova EM (2000). "Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF". J. Biol. Chem. 275 (38): 29915–21. doi:10.1074/jbc.M001538200. PMID 10906122. 
  5. ^ Okamoto T, Izumi H, Imamura T, Takano H, Ise T, Uchiumi T, Kuwano M, Kohno K (2000). "Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression". Oncogene 19 (54): 6194–202. doi:10.1038/sj.onc.1204029. PMID 11175333. 
  6. ^ Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6. PMID 9927044. 
  7. ^ Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". J. Mol. Biol. 384 (4): 908–16. doi:10.1016/j.jmb.2008.09.060. PMID 18851979. 
  8. ^ Raffetseder U, Frye B, Rauen T, Jürchott K, Royer HD, Jansen PL, Mertens PR (2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi:10.1074/jbc.M212518200. PMID 12604611. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.