MXD4

MXD4
Identifiers
Aliases	MXD4, MAD4, MST149, MSTP149, bHLHc12, MAX dimerization protein 4
External IDs	MGI: 104991; HomoloGene: 4712; GeneCards: MXD4; OMA:MXD4 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4p16.3 Start 2,247,432 bp End 2,262,109 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 B2|5 17.84 cM Start 34,331,227 bp End 34,345,064 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior pituitary right lung apex of heart right adrenal cortex Descending thoracic aorta tibial nerve ascending aorta right coronary artery right lobe of thyroid gland Top expressed in ascending aorta aortic valve Paneth cell fossa Rostral migratory stream left lung lobe calvaria vestibular sensory epithelium thymus vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding protein dimerization activity transcription corepressor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10608 17122 Ensembl ENSG00000123933 ENSMUSG00000037235 UniProt Q14582 Q60948 RefSeq (mRNA) NM_006454 NM_010753 RefSeq (protein) NP_006445 n/a Location (UCSC) Chr 4: 2.25 – 2.26 Mb Chr 5: 34.33 – 34.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.

Function

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Marcotte R, Chen JM, Huard S, Wang E (December 2005). "c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts". Journal of Cellular Biochemistry. 96 (5): 1071–85. doi:10.1002/jcb.20503. PMID 16167342. S2CID 8251961.
• Pope SN, Lee IR (February 2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". The Journal of Steroid Biochemistry and Molecular Biology. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
• Jiang DJ, Yu HX, Hexige SY, Guo ZK, Wang X, Ma LJ, Chen Z, Zhao SY, Yu L (July 2004). "Human liver specific transcriptional factor TCP10L binds to MAD4". Journal of Biochemistry and Molecular Biology. 37 (4): 402–7. doi:10.5483/bmbrep.2004.37.4.402. PMID 15469726.
• Kime L, Wright SC (February 2003). "Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc". The Biochemical Journal. 370 (Pt 1): 291–8. doi:10.1042/BJ20021679. PMC 1223147. PMID 12418961.
• Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181.
• Billin AN, Eilers AL, Queva C, Ayer DE (December 1999). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". The Journal of Biological Chemistry. 274 (51): 36344–50. doi:10.1074/jbc.274.51.36344. PMID 10593926.

External links

• MXD4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.