NKX6-2

NKX6-2
Identifiers
Aliases	NKX6-2, GTX, NKX6.2, NKX6B, NK6 homeobox 2, SPAX8
External IDs	OMIM: 605955; MGI: 1352738; HomoloGene: 18580; GeneCards: NKX6-2; OMA:NKX6-2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	132,786,147 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,162,713 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; substantia nigra; ; putamen; ; hippocampus proper; ; primary visual cortex; ; apex of heart; ; temporal lobe; ; amygdala; ; hypothalamus; ; caudate nucleus;
	Top expressed in
	lumbar subsegment of spinal cord; ; ascending aorta; ; aortic valve; ; epithelium of gastric gland; ; substantia nigra; ; spermatid; ; spermatocyte; ; superior frontal gyrus; ; primary visual cortex; ; primordial pancreas;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; positive regulation of glial cell differentiation; cell differentiation; oligodendrocyte differentiation; negative regulation of glial cell differentiation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; negative regulation of cell fate commitment; neuromuscular process controlling balance; positive regulation of cell fate commitment; central nervous system myelination; endocrine pancreas development; regulation of myelination; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	84504
	14912
	ENSG00000148826
	ENSMUSG00000041309
	Q9C056
	D3Z4R4
	NM_177400
	NM_183248
	NP_796374
	NP_899071
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-6.2 is a protein that in humans is encoded by the NKX6-2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148826 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041309 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee SH, Davison JA, Vidal SM, Belouchi A (February 2001). "Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors". Mamm. Genome. 12 (2): 157–62. doi:10.1007/s003350010247. PMID 11210186. S2CID 22368753.
^ "Entrez Gene: NK6 homeobox 2".

References

Further reading