ZBTB20

ZBTB20
Identifiers
Aliases	ZBTB20, DPZF, HOF, ODA-8S, ZNF288, PRIMS, zinc finger and BTB domain containing 20
External IDs	OMIM: 606025; MGI: 1929213; HomoloGene: 9226; GeneCards: ZBTB20; OMA:ZBTB20 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q13.31 Start 114,314,500 bp End 115,147,288 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 B4|16 28.44 cM Start 42,875,881 bp End 43,642,602 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis caput epididymis tail of epididymis renal medulla corpus callosum Achilles tendon Skeletal muscle tissue of biceps brachii external globus pallidus trigeminal ganglion glutes Top expressed in Rostral migratory stream vestibular membrane of cochlear duct utricle median eminence arcuate nucleus ciliary body aortic valve ascending aorta tunica media of zone of aorta retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm nuclear body cytoplasm Biological process positive regulation of tumor necrosis factor production negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II negative regulation of gene expression transcription, DNA-templated positive regulation of interleukin-6 production positive regulation of interferon-beta production positive regulation of glycolytic process positive regulation of lipid biosynthetic process lipid homeostasis cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26137 56490 Ensembl ENSG00000181722 ENSMUSG00000022708 UniProt Q9HC78 Q8K0L9 RefSeq (mRNA) NM_001164342 NM_001164343 NM_001164344 NM_001164345 NM_001164346 NM_001164347 NM_015642 NM_001348800 NM_001348802 NM_001348803 NM_001348804 NM_001348805 NM_001348801 NM_001393393 NM_001393394 NM_001393395 NM_001393396 NM_001285805 NM_019778 NM_181058 RefSeq (protein) NP_001157814 NP_001157815 NP_001157816 NP_001157817 NP_001157818 NP_001157819 NP_056457 NP_001335729 NP_001335731 NP_001335732 NP_001335733 NP_001335734 NP_001335730 NP_001272734 NP_062752 NP_851401 NP_001380326 NP_001380327 NP_001380328 Location (UCSC) Chr 3: 114.31 – 115.15 Mb Chr 16: 42.88 – 43.64 Mb PubMed search
Wikidata
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Zinc finger and BTB domain-containing protein 20 is a protein that in humans is encoded by the ZBTB20 gene.

There is evidence that ZBTB20 may cause primrose disease.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Cordeddu, Viviana; Redeker, Bert; Stellacci, Emilia; Jongejan, Aldo; Fragale, Alessandra; Bradley, Ted E. J.; Anselmi, Massimiliano; Ciolfi, Andrea; Cecchetti, Serena; Muto, Valentina; Bernardini, Laura; Azage, Meron; Carvalho, Daniel R.; Espay, Alberto J.; Male, Alison; Molin, Anna-Maja; Posmyk, Renata; Battisti, Carla; Casertano, Alberto; Melis, Daniela; van Kampen, Antoine; Baas, Frank; Mannens, Marcel M.; Bocchinfuso, Gianfranco; Stella, Lorenzo; Tartaglia, Marco; Hennekam, Raoul C. (August 2014). "Mutations in ZBTB20 cause Primrose syndrome". Nature Genetics. 46 (8): 815–817. doi:10.1038/ng.3035. PMID 25017102. S2CID 23567698.

External links

• ZBTB20+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.