Neurogenin-2

NEUROG2
Identifiers
Aliases	NEUROG2, Atoh4, Math4A, NGN2, bHLHa8, ngn-2, neurogenin 2
External IDs	OMIM: 606624 MGI: 109619 HomoloGene: 7633 GeneCards: NEUROG2
Gene location (Human) Chr. Chromosome 4 (human) Band 4q25 Start 112,513,516 bp End 112,516,180 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 G2 Start 127,426,784 bp End 127,429,280 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence putamen amygdala caudate nucleus hippocampus proper prefrontal cortex Achilles tendon Brodmann area 9 mammary gland breast Top expressed in rhombic lip fossa urethra ganglionic eminence pretectal area neural crest condyle zona limitans intrathalamica somite lens More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding E-box binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development nervous system development regulation of transcription, DNA-templated positive regulation of DNA-binding transcription factor activity neuron differentiation cell differentiation transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63973 11924 Ensembl ENSG00000178403 ENSMUSG00000027967 UniProt Q9H2A3 P70447 RefSeq (mRNA) NM_024019 NM_009718 RefSeq (protein) NP_076924 NP_033848 Location (UCSC) Chr 4: 112.51 – 112.52 Mb Chr 3: 127.43 – 127.43 Mb PubMed search
Wikidata
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Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.

Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.

Further reading

• Gradwohl G, Fode C, Guillemot F (1996). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors". Dev. Biol. 180 (1): 227–41. doi:10.1006/dbio.1996.0297. PMID 8948587.
• Simmons AD, Horton S, Abney AL, Johnson JE (2001). "Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers". Dev. Biol. 229 (2): 327–39. doi:10.1006/dbio.2000.9984. PMID 11203697.
• Kumar M, Bagchi B, Gupta SK, et al. (2007). "Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells". Stem Cells Dev. 16 (4): 667–81. doi:10.1089/scd.2006.0115. PMID 17784840.
• Deng S, Deng H, Le W, et al. (2009). "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease". Neurosci. Lett. 468 (3): 195–197. doi:10.1016/j.neulet.2009.10.078. PMID 19879328.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Park CH, Kang JS, Yoon EH, et al. (2008). "Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro". FEBS Lett. 582 (5): 537–42. doi:10.1016/j.febslet.2008.01.018. PMID 18242186.
• Fode C, Gradwohl G, Morin X, et al. (1998). "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons". Neuron. 20 (3): 483–94. doi:10.1016/S0896-6273(00)80989-7. PMID 9539123.