Activating transcription factor
In molecular biology, activating transcription factor, ATF, is a group of bZIP transcription factors, which act as homodimers or heterodimers with a range of other bZIP factors.[1] First, they have been described as members of the CREB/ATF family,[2] whereas it turned out later that some of them might be more similar to AP-1-like factors such as c-Jun or c-Fos.[3]
Genes include ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7.
References
- ^ van Dam H, Castellazzi M (2001). "Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis". Oncogene. 20 (19): 2453–64. doi:10.1038/sj.onc.1204239. PMID 11402340.
- ^ Karin M1, Smeal T (1992). "Control of transcription factors by signal transduction pathways: the beginning of the end". Trends Biochem Sci. 17 (10): 418–22. doi:10.1016/0968-0004(92)90012-x. PMID 1455510.
{{cite journal}}: CS1 maint: numeric names: authors list (link) - ^ "Classification of Human Transcription Factors (TFClass)".
External links
- Activating+Transcription+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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