CBX3

CBX3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TZD, 2L11, 3DM1, 3KUP
Identifiers
Aliases	CBX3, HECH, HP1-GAMMA, HP1Hs-gamma, chromobox 3
External IDs	OMIM: 604477; MGI: 108515; HomoloGene: 40583; GeneCards: CBX3; OMA:CBX3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	26,213,607 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	51,460,684 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ganglionic eminence; ; visceral pleura; ; parietal pleura; ; germinal epithelium; ; tibia; ; trabecular bone; ; endometrium; ; palpebral conjunctiva; ; Brodmann area 23;
	Top expressed in
	morula; ; yolk sac; ; superior frontal gyrus; ; lip; ; spermatid; ; spermatocyte; ; thymus; ; cerebellar cortex; ; neural tube; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; histone methyltransferase binding; protein binding; identical protein binding; enzyme binding;
Cellular component	nuclear envelope; spindle; nuclear inner membrane; chromatin; chromosome, centromeric region; nucleus; condensed chromosome, centromeric region; nucleoplasm; site of DNA damage; senescence-associated heterochromatin focus;
Biological process	chromatin remodeling; regulation of transcription, DNA-templated; rhythmic process; transcription, DNA-templated; negative regulation of transcription, DNA-templated; negative regulation of G0 to G1 transition; chromatin organization; cellular response to DNA damage stimulus; cellular response to dexamethasone stimulus;
	Sources:Amigo / QuickGO
Orthologs
	11335
	12417
	ENSG00000122565
	ENSMUSG00000029836
	Q13185
	P23198
	NM_007276; NM_016587
	NM_001037798; NM_007624; NM_001355002
	NP_009207; NP_057671
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans.^[5]^[6]

Template:PBB Summary

Interactions

CBX3 has been shown to interact with PIM1,^[7] Ki-67,^[8] Lamin B receptor,^[9] CBX5^[10] and CBX1.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122565 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029836 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ye Q, Worman HJ (August 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem. 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. PMID 8663349.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)".
^ Koike, N; Maita H; Taira T; Ariga H; Iguchi-Ariga S M (February 2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. 467 (1). NETHERLANDS: 17–21. doi:10.1016/S0014-5793(00)01105-4. ISSN 0014-5793. PMID 10664448. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Kametaka, Ai; Takagi Masatoshi; Hayakawa Tomohiro; Haraguchi Tokuko; Hiraoka Yasushi; Yoneda Yoshihiro (December 2002). "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins". Genes Cells. 7 (12). England: 1231–42. doi:10.1046/j.1365-2443.2002.00596.x. ISSN 1356-9597. PMID 12485163. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Ye, Q; Worman H J (June 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J. Biol. Chem. 271 (25). UNITED STATES: 14653–6. doi:10.1074/jbc.271.25.14653. ISSN 0021-9258. PMID 8663349. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
^ ^a ^b Nielsen, A L; Oulad-Abdelghani M; Ortiz J A; Remboutsika E; Chambon P; Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4). United States: 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

External links

CBX3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CBX3 genome location and CBX3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Template:PBB Controls

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122565 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029836 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8663349-5] Ye Q, Worman HJ (August 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem. 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. PMID 8663349.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[entrez-6] "Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)".

[pmid10664448-7] Koike, N; Maita H; Taira T; Ariga H; Iguchi-Ariga S M (February 2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. 467 (1). NETHERLANDS: 17–21. doi:10.1016/S0014-5793(00)01105-4. ISSN 0014-5793. PMID 10664448. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[pmid12485163-8] Kametaka, Ai; Takagi Masatoshi; Hayakawa Tomohiro; Haraguchi Tokuko; Hiraoka Yasushi; Yoneda Yoshihiro (December 2002). "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins". Genes Cells. 7 (12). England: 1231–42. doi:10.1046/j.1365-2443.2002.00596.x. ISSN 1356-9597. PMID 12485163. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[autogenerated1-9] Ye, Q; Worman H J (June 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J. Biol. Chem. 271 (25). UNITED STATES: 14653–6. doi:10.1074/jbc.271.25.14653. ISSN 0021-9258. PMID 8663349. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

[pmid11336697-10] Nielsen, A L; Oulad-Abdelghani M; Ortiz J A; Remboutsika E; Chambon P; Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4). United States: 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

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CBX3

Interactions

See also

References

Further reading

External links