FOXP4

FOXP4
Identifiers
Aliases	FOXP4, hFKHLA, forkhead box P4
External IDs	OMIM: 608924; MGI: 1921373; HomoloGene: 12536; GeneCards: FOXP4; OMA:FOXP4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	41,602,384 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	48,235,570 bp
RNA expression pattern
	Top expressed in
	pylorus; ; body of stomach; ; cardia; ; cardiac muscle tissue of right atrium; ; ganglionic eminence; ; fundus; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; myocardium of left ventricle;
	Top expressed in
	sphenoid bone; ; genital tubercle; ; lesser wing of sphenoid bone; ; basisphenoid; ; ganglionic eminence; ; yolk sac; ; ventricular zone; ; urinary bladder; ; primary visual cortex; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; protein binding; metal ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	116113
	74123
	ENSG00000137166
	ENSMUSG00000023991
	Q8IVH2
	Q9DBY0
NM_001012426; NM_001012427; NM_138457; NM_001405824; NM_001405825;
	NM_001405826
	NM_001110824; NM_001110825; NM_028767
	NP_001012426; NP_001012427; NP_612466
	NP_001104294; NP_001104295; NP_083043; NP_001390898; NP_001390899
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene.^[5]

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.^[5] It also is a major factor in developing Long COVID as such, increasing the chances of developing the little-understood syndrome 1.6 fold, a finding which has major implications for COVID-19 pandemic research.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137166 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023991 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: FOXP4 forkhead box P4".
^ Ledford H (July 11, 2023). "Gene linked to long COVID found in analysis of thousands of patients". Nature. 619 (7970): 445. Bibcode:2023Natur.619..445L. doi:10.1038/d41586-023-02269-2. PMID 37433943. S2CID 259831412 – via www.nature.com.

Katoh M, Katoh M (2005). "Human FOX gene family (Review)". Int. J. Oncol. 25 (5): 1495–500. doi:10.3892/ijo.25.5.1495. PMID 15492844.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lu MM, Li S, Yang H, Morrisey EE (2003). "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Gene Expr. Patterns. 2 (3–4): 223–8. doi:10.1016/S1567-133X(02)00058-3. PMID 12617805. (Retracted, see doi:10.1016/S0925-4773(03)00085-6)
Teufel A, Wong EA, Mukhopadhyay M, Malik N, Westphal H (2003). "FoxP4, a novel forkhead transcription factor". Biochim. Biophys. Acta. 1627 (2–3): 147–52. doi:10.1016/S0167-4781(03)00074-5. PMID 12818433.
Lu MM, Li S, Yang H, Morrisey EE (2002). "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Mech. Dev. 119 (Suppl 1): S197–202. doi:10.1016/S0925-4773(03)00116-3. PMID 14516685. S2CID 935988.
Li S, Weidenfeld J, Morrisey EE (2004). "Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions". Mol. Cell. Biol. 24 (2): 809–22. doi:10.1128/MCB.24.2.809-822.2004. PMC 343786. PMID 14701752.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, Morrisey EE, Margulies KB, Cappola TP (2006). "Transcriptional genomics associates FOX transcription factors with human heart failure". Circulation. 114 (12): 1269–76. doi:10.1161/CIRCULATIONAHA.106.632430. PMID 16952980.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137166 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023991 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FOXP4 forkhead box P4".

[6] Ledford H (July 11, 2023). "Gene linked to long COVID found in analysis of thousands of patients". Nature. 619 (7970): 445. Bibcode:2023Natur.619..445L. doi:10.1038/d41586-023-02269-2. PMID 37433943. S2CID 259831412 – via www.nature.com.

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References

Further reading