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Myeloid/lymphoid or mixed-lineage leukemia 4
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MLL4 ; HRX2; KMT2B; MLL2; TRX2; WBP7
External IDs OMIM606834 MGI109565 HomoloGene22838 GeneCards: MLL4 Gene
EC number
RNA expression pattern
PBB GE MLL4 203419 at tn.png
PBB GE MLL4 217075 x at tn.png
More reference expression data
Species Human Mouse
Entrez 9757 75410
Ensembl ENSG00000105663 ENSMUSG00000006307
UniProt Q9UMN6 O08550
RefSeq (mRNA) NM_014727 NM_029274
RefSeq (protein) NP_055542 NP_083550
Location (UCSC) Chr 19:
36.21 – 36.23 Mb
Chr 7:
30.57 – 30.59 Mb
PubMed search [1] [2]

Myeloid/lymphoid or mixed-lineage leukemia 4, also known as MLL4, is a human gene.[1]

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.[1]


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.