MLL4

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KMT2B
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KMT2B, HRX2, MLL1B, MLL2, MLL4, TRX2, WBP-7, WBP7, CXXC10, lysine methyltransferase 2B, DYT28
External IDs MGI: 109565 HomoloGene: 22838 GeneCards: KMT2B
RNA expression pattern
PBB GE MLL4 217075 x at fs.png

PBB GE MLL4 203419 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014727

NM_001290573
NM_029274

RefSeq (protein)

NP_055542

NP_083550.2
NP_001277502
NP_083550

Location (UCSC) Chr 19: 35.72 – 35.74 Mb Chr 7: 30.57 – 30.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Myeloid/lymphoid or mixed-lineage leukemia 4, also known as MLL4, is a human gene.[3]

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.[3]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.