NFATC4

NFATC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YRP
Identifiers
Aliases	NFATC4, NF-AT3, NF-ATC4, NFAT3, nuclear factor of activated T-cells 4, nuclear factor of activated T cells 4
External IDs	OMIM: 602699; MGI: 1920431; HomoloGene: 3349; GeneCards: NFATC4; OMA:NFATC4 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q12 Start 24,365,673 bp End 24,379,604 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 C3 Start 56,060,601 bp End 56,071,400 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in canal of the cervix right ovary left ovary stromal cell of endometrium body of uterus left uterine tube myometrium gastric mucosa muscle layer of sigmoid colon right coronary artery Top expressed in gastrula external carotid artery internal carotid artery genital tubercle maxillary prominence mandibular prominence ventricular zone hand calvaria abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity transcription coactivator activity transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific peroxisome proliferator activated receptor binding chromatin binding Cellular component transcription regulator complex nucleus cytoplasm cytosol nuclear speck Biological process cell differentiation regulation of transcription, DNA-templated cellular response to lithium ion negative regulation of chromatin binding cellular response to UV negative regulation of Wnt signaling pathway calcineurin-NFAT signaling cascade positive regulation of apoptotic signaling pathway negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of protein binding smooth muscle cell differentiation transcription, DNA-templated regulation of synaptic plasticity negative regulation of synapse maturation heart development negative regulation of dendrite morphogenesis intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of tumor necrosis factor production branching involved in blood vessel morphogenesis cellular respiration positive regulation of apoptotic process inflammatory response muscle cell development positive regulation of transcription by RNA polymerase II negative regulation of pri-miRNA transcription by RNA polymerase II cellular response to ionomycin cytokine production long-term memory brain-derived neurotrophic factor receptor signaling pathway negative regulation of neuron apoptotic process long-term potentiation multicellular organism development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4776 73181 Ensembl ENSG00000100968 ENSG00000285485 ENSMUSG00000023411 UniProt Q14934 Q8K120 RefSeq (mRNA) NM_001136022 NM_001198965 NM_001198966 NM_001198967 NM_001288802 NM_004554 NM_001320043 NM_001363681 NM_001363682 NM_001168346 NM_023699 RefSeq (protein) NP_001129494 NP_001185894 NP_001185895 NP_001185896 NP_001275731 NP_001306972 NP_004545 NP_001350610 NP_001350611 NP_001161818 NP_076188 Location (UCSC) Chr 14: 24.37 – 24.38 Mb Chr 14: 56.06 – 56.07 Mb PubMed search
Wikidata
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Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.

Function

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.

NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation. Indeed NFAT3 (NFATc4) is an inhibitor of cell motility by blocking the expression of LCN2.

Interactions

NFATC4 has been shown to interact with CREB-binding protein.

See also

• NFAT

Further reading

• Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annual Review of Immunology. 15: 707–47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.
• Crabtree GR (Mar 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): 611–4. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876.
• Horsley V, Pavlath GK (Mar 2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". The Journal of Cell Biology. 156 (5): 771–4. doi:10.1083/jcb.200111073. PMC 2173310. PMID 11877454.
• Jabado N, Le Deist F, Fisher A, Hivroz C (Nov 1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology. 24 (11): 2646–52. doi:10.1002/eji.1830241112. PMID 7957556.
• Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A (Nov 1994). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochemical and Biophysical Research Communications. 205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID 7999066.
• Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT (Sep 1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". European Journal of Immunology. 26 (9): 2181–8. doi:10.1002/eji.1830260933. PMID 8814265.
• Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN (Apr 1998). "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy". Cell. 93 (2): 215–28. doi:10.1016/S0092-8674(00)81573-1. PMID 9568714.
• Aramburu J, Garcia-Cózar F, Raghavan A, Okamura H, Rao A, Hogan PG (Apr 1998). "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT". Molecular Cell. 1 (5): 627–37. doi:10.1016/S1097-2765(00)80063-5. PMID 9660947.
• Chow CW, Davis RJ (Jan 2000). "Integration of calcium and cyclic AMP signaling pathways by 14-3-3". Molecular and Cellular Biology. 20 (2): 702–12. doi:10.1128/MCB.20.2.702-712.2000. PMC 85175. PMID 10611249.
• Graef IA, Chen F, Chen L, Kuo A, Crabtree GR (Jun 2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature". Cell. 105 (7): 863–75. doi:10.1016/S0092-8674(01)00396-8. PMID 11439183.
• Yang T, Davis RJ, Chow CW (Oct 2001). "Requirement of two NFATc4 transactivation domains for CBP potentiation". The Journal of Biological Chemistry. 276 (43): 39569–76. doi:10.1074/jbc.M102961200. PMID 11514544.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Yang TT, Xiong Q, Enslen H, Davis RJ, Chow CW (Jun 2002). "Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases". Molecular and Cellular Biology. 22 (11): 3892–904. doi:10.1128/MCB.22.11.3892-3904.2002. PMC 133816. PMID 11997522.
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (Nov 2002). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
• Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR (May 2003). "Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons". Cell. 113 (5): 657–70. doi:10.1016/S0092-8674(03)00390-8. PMID 12787506.
• Lahti AL, Manninen A, Saksela K (May 2003). "Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB". Virology. 310 (1): 190–6. doi:10.1016/S0042-6822(03)00164-8. PMID 12788643.

External links

• NFATC4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.