NKX2-3

NKX2-3
Identifiers
Aliases	NKX2-3, CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3, NK2 homeobox 3
External IDs	OMIM: 606727; MGI: 97348; HomoloGene: 17061; GeneCards: NKX2-3; OMA:NKX2-3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	99,536,524 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	43,604,331 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; spleen; ; transverse colon; ; duodenum; ; sural nerve; ; minor salivary glands; ; jejunal mucosa; ; mucosa of transverse colon; ; cecum; ; rectum;
	Top expressed in
	Hindgut; ; migratory enteric neural crest cell; ; yolk sac; ; Stomodeum; ; buccopharyngeal membrane; ; duodenum; ; pharyngeal pouch; ; ileum; ; tongue; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; molecular function; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity;
Cellular component	nucleus; cellular component;
Biological process	leukocyte homeostasis; CD4-positive, alpha-beta T cell differentiation; post-embryonic digestive tract morphogenesis; regulation of transcription, DNA-templated; plasma cell differentiation; spleen development; post-embryonic development; transcription, DNA-templated; macrophage differentiation; mucosa-associated lymphoid tissue development; odontogenesis of dentin-containing tooth; gland morphogenesis; regulation of cell population proliferation; immune response; B cell differentiation; Peyer's patch development; digestive tract development; lymph node development; triglyceride metabolic process; leukocyte migration; positive regulation of transcription by RNA polymerase II; biological process; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	159296
	18089
	ENSG00000119919
	ENSMUSG00000044220
	Q8TAU0
	P97334
	NM_145285
	NM_008699
	NP_660328
	NP_032725
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119919 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044220 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742.
^ Pabst O, Schneider A, Brand T, Arnold HH (Jul 1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development". Dev Dyn. 209 (1): 29–35. doi:10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z. PMID 9142493.
^ "Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)".

References

Further reading