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POU4F2

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POU4F2
Identifiers
AliasesPOU4F2, BRN3.2, BRN3B, Brn-3b, POU class 4 homeobox 2
External IDsOMIM: 113725; MGI: 102524; HomoloGene: 20959; GeneCards: POU4F2; OMA:POU4F2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004575

NM_138944

RefSeq (protein)

NP_004566

NP_620394

Location (UCSC)Chr 4: 146.64 – 146.64 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.[4][5]

Function

POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM][5]

Interactions

POU4F2 has been shown to interact with Estrogen receptor alpha.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151615Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Ring CJ, Latchman DS (Jun 1993). "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain". Nucleic Acids Research. 21 (12): 2946. doi:10.1093/nar/21.12.2946. PMC 309696. PMID 8332509.
  5. ^ a b "Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2".
  6. ^ Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Molecular and Cellular Biology. 18 (2): 1029–41. doi:10.1128/mcb.18.2.1029. PMC 108815. PMID 9448000.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.