From Wikipedia, the free encyclopedia
T-cell acute lymphocytic leukemia 2 , also known as TAL2 , is a protein which in humans is encoded by the TAL2 gene .[ 5] [ 6]
Function
TAL2 is a member of the basic helix-loop-helix family of transcription factors .[ 7]
Clinical significance
Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).[ 6] [ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000186051 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028417 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2" .
^ a b Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia" . Proc. Natl. Acad. Sci. U.S.A . 88 (24): 11416–20. doi :10.1073/pnas.88.24.11416 . PMC 53146 . PMID 1763056 .
^ Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia". Semin. Cancer Biol . 4 (6): 341–7. PMID 8142619 .
^ Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B (March 2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet . 33 (3): 342–4. doi :10.1038/ng1092 . PMID 12567187 .
Further reading
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group C bHLH-PAS Group D Group E Group F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
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