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{{cs1 config |name-list-style=vanc |display-authors=6}}
{{cs1 config |name-list-style=vanc |display-authors=6}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Protein C-ETS2''' is a [[protein]] that in humans is encoded by the ''ETS2'' [[gene]].<ref name="pmid17986575">{{cite journal | vauthors = Dwyer J, Li H, Xu D, Liu JP | title = Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family | journal = Annals of the New York Academy of Sciences | volume = 1114 | issue = 1 | pages = 36–47 | date = Oct 2007 | pmid = 17986575 | doi = 10.1196/annals.1396.022 | bibcode = 2007NYASA1114...36D | s2cid = 44532648 }}</ref><ref>{{cite web | title = Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2114}}</ref> The [[protein]] encoded by this gene belongs to the [[ETS transcription factor family|ETS family of transcription factor]]s.<ref name="pmid17986575" /> It has been found to play a key role in the development of [[inflammatory bowel disease]].<ref name="pmid36609474">{{cite journal | vauthors = Chen Y, Ying Y, Wang M, Ma C, Jia M, Shi L, Wang S, Zheng X, Chen W, Shu XS | title = A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer | journal = Cell Death & Disease | volume = 14 | issue = 1 | pages = 8 | date = January 2023 | pmid = 36609474 | pmc = 9822945 | doi = 10.1038/s41419-022-05513-1 }}</ref><ref>{{cite journal | vauthors = Stankey CT, Bourges C, Haag LM, Turner-Stokes T, Piedade AP, Palmer-Jones C, Papa I, Silva dos Santos M, Zhang Q, Cameron AJ, Legrini A | title = A disease-associated gene desert directs macrophage inflammation through ETS2. | journal = Nature | date = June 2024 | doi = 10.1038/s41586-024-07501-1 | doi-access = free }}</ref>
'''Protein C-ETS2''' is a [[protein]] that in humans is encoded by the ''ETS2'' [[gene]].<ref name="pmid17986575">{{cite journal | vauthors = Dwyer J, Li H, Xu D, Liu JP | title = Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family | journal = Annals of the New York Academy of Sciences | volume = 1114 | issue = 1 | pages = 36–47 | date = Oct 2007 | pmid = 17986575 | doi = 10.1196/annals.1396.022 | bibcode = 2007NYASA1114...36D | s2cid = 44532648 }}</ref><ref>{{cite web | title = Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2114}}</ref> The [[protein]] encoded by this gene belongs to the [[ETS transcription factor family|ETS family of transcription factor]]s.<ref name="pmid17986575" /> It has been found to play a key role in the development of [[inflammatory bowel disease]].<ref name="pmid36609474">{{cite journal | vauthors = Chen Y, Ying Y, Wang M, Ma C, Jia M, Shi L, Wang S, Zheng X, Chen W, Shu XS | title = A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer | journal = Cell Death & Disease | volume = 14 | issue = 1 | pages = 8 | date = January 2023 | pmid = 36609474 | pmc = 9822945 | doi = 10.1038/s41419-022-05513-1 }}</ref><ref>{{cite journal | vauthors = Stankey CT, Bourges C, Haag LM, Turner-Stokes T, Piedade AP, Palmer-Jones C, Papa I, Silva dos Santos M, Zhang Q, Cameron AJ, Legrini A | title = A disease-associated gene desert directs macrophage inflammation through ETS2. | journal = Nature | date = June 2024 | doi = 10.1038/s41586-024-07501-1 | doi-access = free | pmc = 11168933 }}</ref>


== Interactions ==
== Interactions ==

Revision as of 06:17, 17 June 2024

For the video game, see Euro Truck Simulator 2.
ETS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesETS2, ETS2IT1, ETS proto-oncogene 2, transcription factor
External IDsOMIM: 164740; MGI: 95456; HomoloGene: 3838; GeneCards: ETS2; OMA:ETS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

2114

23872

Ensembl

ENSG00000157557

ENSMUSG00000022895

UniProt

P15036

P15037

RefSeq (mRNA)

NM_001256295
NM_005239

NM_011809

RefSeq (protein)

NP_001243224
NP_005230

NP_035939

Location (UCSC)Chr 21: 38.81 – 38.82 MbChr 16: 95.5 – 95.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein C-ETS2 is a protein that in humans is encoded by the ETS2 gene.[5][6] The protein encoded by this gene belongs to the ETS family of transcription factors.[5] It has been found to play a key role in the development of inflammatory bowel disease.[7][8]

Interactions

ETS2 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157557 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022895 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Dwyer J, Li H, Xu D, Liu JP (Oct 2007). "Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family". Annals of the New York Academy of Sciences. 1114 (1): 36–47. Bibcode:2007NYASA1114...36D. doi:10.1196/annals.1396.022. PMID 17986575. S2CID 44532648.
  6. ^ "Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)".
  7. ^ Chen Y, Ying Y, Wang M, Ma C, Jia M, Shi L, et al. (January 2023). "A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer". Cell Death & Disease. 14 (1): 8. doi:10.1038/s41419-022-05513-1. PMC 9822945. PMID 36609474.
  8. ^ Stankey CT, Bourges C, Haag LM, Turner-Stokes T, Piedade AP, Palmer-Jones C, et al. (June 2024). "A disease-associated gene desert directs macrophage inflammation through ETS2". Nature. doi:10.1038/s41586-024-07501-1. PMC 11168933.
  9. ^ a b Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (Oct 1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner". The Journal of Biological Chemistry. 272 (42): 26188–95. doi:10.1074/jbc.272.42.26188. PMID 9334186.
  10. ^ Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931.
  11. ^ Dudek H, Tantravahi RV, Rao VN, Reddy ES, Reddy EP (Feb 1992). "Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1291–5. Bibcode:1992PNAS...89.1291D. doi:10.1073/pnas.89.4.1291. PMC 48435. PMID 1741383.
  12. ^ Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID 12894593.

Further reading

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